Fragmentation patterns of novel dispirocyclopiperazinium dibromides during electrospray ionization mass spectrometry

doi:10.5246/jcps.2011.01.006

Abstract

Abstract:

The fragmentation patterns of a series of dispirocyclopiperazinium dibromides with strong analgesic activity during positive ion electrospray ionization mass spectrometry were analyzed. The [M-Br]⁺ 2 ions showed the characteristic isotopic peaks and were assigned as the molecular ions. The loss of a 44 Dalton unit from 2 produced ion 3 [M-Br-44]⁺and the loss of HBr from 2 formed ion 4. Besides, the carbamates 1d-1e produced extra ions [M-2Br-33]⁺. The related fragmentation mechanisms were proposed.

Key words: Mass spectrometry, Dispirocyclopiperazinium dibromides, Fragmentation pathway

CLC Number:

R917

Supporting:

Xin Wang, Ang Li, Wei Wang, Run-Tao Li^* . Fragmentation patterns of novel dispirocyclopiperazinium dibromides during electrospray ionization mass spectrometry[J]. , DOI: 10.5246/jcps.2011.01.006.

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