Chemical constituents isolated from Saruma henryi

Abstract

Abstract:

Chemical constituents of the whole herb of Saruma henryi Oliv. were investigated. The herbal extract was separated by repeated column chromatography over silica gel and celite. The structures were elucidated by spectroscopic analysis. Thirteen compounds were obtained and identified as 7-methoxyl-aristololactam IV (1), aristololactam II (2), aristolochic acid I (3), aristololactam AII (4), daucosterol (5), aristololactam Ia (6), N-trans-feruloyl tyramine (7), aristololactam I (8), 4β,10β-aromadendranediol (9), aristololide (10), aristolic acid I (11), meso-dihydroguaiaretic acid (12), and calopiptin (13). These compounds were obtained from the genus Saruma for the first time, and they provided chemical evidences for the chemotaxonomy of plants of the Aristolochiaceae family. Since aristolochic acids and aristololactams are toxic to kidney, the results of this investigation suggest that it should be cautious to use Saruma henryi as a medicine.

Key words: Aristolochiaceae, Aristolochiaceae, Saruma henryi, Saruma henryi, Chemical constituents, Chemical constituents, Aristolochic acid, Aristolochic acid, Aristololactam, Aristololactam

CLC Number:

R284.2

Supporting:

Shi-Wen Dong, Ming-Ying Shang, Xuan Wang^*, Shu-Xiang Zhang, Chen Li, Shao-Qing Cai. Chemical constituents isolated from Saruma henryi[J]. .

References

[1] Delectis Florae Reipublicae Popularis Sinicae Agendae Academiae Sinicae Edita. Flora Reipublicae Popularis Sinicae’ (Zhongguo Zhiwuzhi), Tomus 24. Beijing: Science Press, 1988, 159.

[2] Jiangsu New Medical College. Dictionary of Chinese Materia Medica. Shanghai: Shanghai Scientific and Technical Publishers, 1986.

[3] Wang, J.L.; Yang, C.S.; Du, H.Y.; Shi, S.G. China J. Chin. Mater. Med. 1994, 19, 736-737.

[4] Xu, W.Y.; Yuan, W.H.; Wang, G.L.; Diao, P.X. J. Xi’an Med. Univ. 1996, 17, 74-76.

[5] Iwashina, T.; Marubashi, W.; Suzuki, T. Biochem. Syst. Ecol. 2002, 30, 1101-1103.

[6] Ding, Z.H.; Yiao, L.H.; Chen, Z.L.; Ding, J.K. Acta Bot. Yunnan. 1994, 16, 305-308.

[7] Mix, D.B.; Guinaudeau, H.; Shamma, M. J. Nat. Prod. 1982, 45, 657-666.

[8] Priestap, H.A. Phytochemistry. 1985, 24, 849-852.

[9] Fukuda, N.; Yonemitsu, M.; Kimura, T. Chem. Pharm. Bull. 1983, 31, 156-161.

[10] Goldsby, G.; Burke, B.A. Phytochemistry. 1987, 26, 1059-1063.

[11] Beechan, C.M.; Djerassi, C.; Eggert, H. Tetrahedron. 1978, 34, 2503-2508.

[12] Wu, T.S.; Chan, Y.Y.; Leu, Y.L. Chem. Pharm. Bull. 2000, 48, 357-361.

[13] Achari, B.; Bandyopadhyay, S.; Saha, C.R. Heterocycles. 1983, 20, 771-774.

[14] Pakrashi, S.C.; Ghosh Dastidar, P.; Basu, S.; Achari, B. Phytochemistry. 1977, 16, 1103-1104.

[15] Wang, L.W.; Zhou, C.X.; Schneider, B.; Zhao, Y. Chin. JMAP. 2006, 23, 363-365.

[16] Lopes, N.P.; de Almeida Blumenthal E.E.; Cavalheiro, A.J.; Kato, M.J.; Yoshida, M. Phytochemistry. 1996, 43, 1089-1092.

[17] Doskoch, R.W.; Flom, M.S. Tetrahedron. 1972, 28, 4711-4717.

[18] Riggs, N.V.; Stevens, J.D. Aust. J. Chem. 1962, 15, 305-313.

[19] Takaoka, D.; Watanabe, K.; Hiroi, M. Bull. Chem. Soc. Jpn. 1976, 49, 3564-3566.

[20] Wen, Y.J.; Tao, S.; Tang, J.W.; Zhang, C.Y.; Wang, X.; Cai, S.Q.; Li, X.M. Nephron Exp. Nephrol. 2006, 103, 95-102.

[21] Arlt, V.M.; Stiborova, M.; Schmeiser, H.H. Mutagenesis. 2002, 17, 265-277.

[22] Gillerot, G.; Jadoul, M.; Arlt, V.M.; de Strihou, C.V.Y.; Schmeiser, H.H.; But, P.P.H.; Bieler, C.A.; Cosyns, J.P. Am. J. Kidney Dis. 2001, 38, 1141-1142.

[23] Li, X.M.; Wang, H.Y. Nephrology. 2004, 9, 109-111.

[24] Yang, C.S.; Zeng, W.Z. Medicinal Botany. Shanghai: Science and Technology Press, 1997.