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Chemical constituents from Sappan Lignum

Yu-Ping Chen, Lei Liu, Yu-Hong Zhou, Jing Wen, Yong Jiang, Peng-Fei Tu*   

  1. Peking University Modern Research Center for Traditional Chinese Medicines, Beijing 100083, China
  • Received:2007-10-09 Revised:2008-01-10 Online:2008-03-15 Published:2008-03-15
  • Contact: Peng-Fei Tu*

Abstract:

To study the chemical constituents of Sappan Lignum. Chemical constituents were isolated by method of solvent extraction, repeated chromatography with silica gel, Sephadex LH-20, and ODS. The structures were elucidated based on spectroscopic data. Fourteen compounds were isolated and their structures were identified as brazilin (1), sappanone B (2), (E)-3-(3,4-dihydroxybenzylidene)-7-hydroxychroman-4-one (3), 3-deoxysappanone B (4), brazilide A (5), euxanthone (6), quercetin (7), rhamnetin (8), sappanchalcone (9), 3-deoxysappanchalcone (10), butein (11), 2,4,5-trihydroxybenzaldehyde (12), 3,8,9-trihydroxy-6H-benzo[c]chromen-6-one (13) and β-sitosterol (14). Compounds 12 and 13 were two new natural compounds, and the 13C NMR data of compound 13 were reported for the first time. Compound 6 was the first xanthone isolated from the genus Caesalpinia.

Key words: Caesalpinia sappan, Caesalpinia sappan, Chemical constituents, Chemical constituents, Chemotaxonomy, Chemotaxonomy

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