Comparison of effects on bone mesenchymal stem cells differentiation between lanthanum and gadolinium under high phosphate condition

doi:10.5246/jcps.2016.07.059

Abstract

Abstract:

Lanthanum (La) and gadolinium (Gd) have been used in clinical diagnosis and treatment. The application of La and Gd in medication may cause accumulation of the elements in bone. Whether the similar physicochemical properties of these two Lanthanides (Lns) will lead to similar biological effects on bone metabolism in patients with severe kidney failureare key concerns of researchers.This study compared the inﬂuences of LaCl₃ and GdCl₃ on in vitro differentiation of bone mesenchymal stem cells (BMSCs) in high phosphate (Pi) medium. The results showed that LaCl₃ inhibited high Pi-induced BMSC differentiation at higher concentration and stimulated BMSC differentiation-related genes at lower concentration, while GdCl₃ promoted high Pi-induced BMSC differentiation. The emergence of insoluble Ln-containing calcium phosphate (CaP) was implicated in the process of LaCl₃ or GdCl₃ mediated osteogenic differentiation.The small differences in atomic number of La and Gd causedthe more promotive effect of GdCl₃on the precipitation of CaP compared with LaCl₃.Moreover, the content of serum proteins coprecipitated in Gd-containing particles was decreased compared with La-containing particles, leading to larger particle size of Gd-containing particles.The study demonstrated that those distinct physicochemical propertiesof Gd-containing particlesvs. La-containing particlesplayed an important role in modulatingthe different effects of GdCl₃and LaCl₃on BMSC differentiation.

Key words: Lanthanum, Gadolinium, High phosphate, Differentiation

CLC Number:

R916.3

Supporting:

Caixia Yu, Jiao Gong, Jian Huang, Tianlan Zhang, Kui Wang. Comparison of effects on bone mesenchymal stem cells differentiation between lanthanum and gadolinium under high phosphate condition[J]. Journal of Chinese Pharmaceutical Sciences, 2016, 25(7): 535-545.

References

[1] Swainston Harrison, T.; Scott, L.J. Drugs. FDA. 2004, 64, 985-996.
[2] Public Health Advisory—Gadolinium-containing Contrast Agents for Magnetic Resonance Imaging (MRI): Omniscan, OptiMARK, Magnevist, ProHance, and MultiHance. FDA. 2007, Available at: http://www.fda. gov/cder/drug/advisory/gadolinium_agents.htm
[3] Agarwal, R.; Brunelli, S.M.; Williams, K.; Mitchell, M.D.; Feldman, H.I.; Umscheid C.A. Nephrol. Dial. Transplant. 2009, 24, 856-863.
[4] D’Haese, P.C.; Spasovski, G.B.; Sikole, A.; Hutchison, A.; Freemont, T.J.; Sulkov, S.; Swanepoel, C.; Pejanovic, S.; Djukanovic, L.; Balducci, A.; Coen, G.; Sulowicz, W.; Ferreira, A.; Torres, A.; Curic, S.; Popovic, M.; Dimkovic, N.; De Broe, M.E. Kidney. Int. Suppl. 2003, S73-78.
[5] Behets, G.J.; Verberckmoes, S.C.; D'Haese, P.C.; De Broe, M.E. Curr. Opin. Nephrol. Hypertens. 2004, 13, 403-409.
[6] Chiang, S.S.; Chen, J.B.; Yang, W.C. Clin. Nephrol. 2005, 63, 461-470.
[7] Aime, S.; Canavese, C.; Stratta, P. Kidney. Int. 2007, 72, 1162-1163.
[8] Brambilla, S.; Valaperta, S.; Graziani, G.; Montanelli, A. Clin. Biochem. 2008, 41, 1029-1033.
[9] De Broe, M.E. Semin. Dial. 2008, 21, 142-144.
[10] Feyerabend, F.; Fischer, J.; Holtz, J.; Witte, F.; Willumeit, R.; Drücker, H.; Vogt, C.; Hort, N. Acta. Biomater. 2010, 6, 1834-1842.
[11] Pagano, G.; Aliberti, F.; Guida, M.; Oral, R.; Siciliano, A.; Trifuoggi, M.; Tommasi, F. Environ. Res. 2015, 142, 215-220.
[12] Lacour, B.; Lucas, A.; Auchère, D.; Ruellan, N.; De Serre Patey, N.M.; Drüeke, T.B. Kidney. Int. 2005, 67, 1062-1069.
[13] Slatopolsky, E.; Liapis, H.; Finch, J. Kidney. Int. 2006, 68, 2809-2813.
[14] Bronner, F.; Slepchenko, B.M.; Pennick, M.; Damment, S.J. Clin. Pharmacokinet. 2008, 47, 543-552.
[15] Darrah, T.H.; Prutsman-Pfeiffer, J.J.; Poreda, R.J.; Ellen Campbell, M.; Hauschka, P.V.; Hannigan, R.E. Metallomics. 2009, 1, 479-488.
[16] Gibby, W.A. Invest. Radiol. 2004, 39, 138-142.
[17] Fumoto, T.; Ito, M.; Ikeda, K. J. Bone. Miner. Metab. 2014, 32, 484-493.
[18] Von Rosenberg, S.J.; Wehr, U.A. J. Anim. Physiol. Anim. Nutr (Berl). 2012, 96, 885-894.
[19] Damment, S.; Secker, R.; Shen, V.; Lorenzo, V.; Rodriguez, M. Nephrol. Dial. Transplant. 2011, 26, 1803-1812.
[20] Evans, C.H. Biochemistry of the Lanthanide. New York. Plenum Press. 1990.
[21] George, S.J.; Webb, S.M.; Abraham, J.L.; Cramer, S.P. Br. J. Dermatol. 2010, 163, 1077-1108.
[22] Feng, M.; Fan, Y.Z.; Ma, X.J.; Li, J.X.; Yang, X.G. Metallomics. 2015, 7, 1103-1110.
[23] Feng, M.; Li, J.X.; Ma, X.J.; Fan, Y.Z.; Wu, J.X.; Zeng, Q.; Yang, X.G. J. Chin. Pharm. Sci. 2014, 23, 772-777.
[24] Lioliou, M.G.; Paraskeva, C.A.; Koutsoukos, P.G.; Payatakes, A.C. J. Colloid. Interface. Sci. 2007, 308, 421-428.
[25] Anjos-Afonso, F.; Bonnet, D. Curr. Protoc. Stem. Cell. Biol. 2008, 2B.3.1-2B.3.11.
[26] Livak, K.J.; Schmittgen, T.D. Methods. 2001, 25, 402-408.
[27] Seaborg, G.T. Radiochim. Acta. 1993, 61, 115−122.
[28] Duffield, J.R.; Taylor, D.M.; Williams, D.R. Handbook on the Physics and Chemistry of Rare Earths. Amsterdam. Elsevier, 1994, 18, 591−621.
[29] Salimi, M.H.; Heughebaert, J.C.; Nancollas, G.H. Langmuir. 1985, 1, 119-122.
[30] Bigi, A.; Gazzano, M.; Ripamonti, A.; Roveri, N. J. Inorg. Biochem. 1988, 32, 251-257.
[31] Lundager Madsen, H.E. J. Cryst. Growth. 2008, 310, 2602-2261.
[32] Hails, L.A.; Babister, J.C.; Inglis, S.; Davis, S.A.; Oreffo, R.O.; Mann, S. Small. 2010, 6, 1986-1991.
[33] Liu, J.K.; Wang, G.C.; Cai, Y.R.; Ji, H.; Zhou, G.S.; Zhao, X.L.; Tang, R.K.; Zhang, M. J. Biomed. Mat. Res. 2009, 90, 1083-1091.
[34] Albanese, A.; Tang, P.S.; Chan, W.C. Annu. Rev. Biomed. Eng. 2012, 14, 1-16.
[35] Lunov, O.; Zablotskii, V.; Syrovets, T.; Röcker, C.; Tron, K.; Nienhaus, G.U.; Simmet, T. Biomaterials. 2011, 32, 547-555.
[36] Shang, L.; Nienhaus, K.; Nienhaus, G.U. J. Nanobiotechnol. 2014, 12, 5.
[37] Zhang, J.C.; Li, Y.P.; Zhang, Q.; Hao, X.H.; Wang S.X. J. Rare. Earth. 2012, 8, 831-834.
[38] Liu, D.; Zhang, J.; Wang, G.; Liu, X.; Wang, S.; Yang, M. Biol. Trace. Elem. Res. 2012, 150, 433-440.

Comparison of effects on bone mesenchymal stem cells differentiation between lanthanum and gadolinium under high phosphate condition

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 12

Recommended Articles

Metrics

Comments

[1]	Chuan Qin, Qi Wan, Lei Xi, Mian Wei, Quan Du. A pharmacological study of pioglitazone in the regulation of adipocyte differentiation [J]. Journal of Chinese Pharmaceutical Sciences, 2022, 31(3): 176-183.
[2]	Xu Quan, Caihong Gu, Feng Yan, Yaoyao Gao, Lin Chen, Rong Wei, Bingchun Yan, Rong Hu. Porcine placental peptides improve neuroblast proliferation and differentiation via enhancement of TrkB and BDNF levels in D-glatacose-induced mouse aging model [J]. Journal of Chinese Pharmaceutical Sciences, 2019, 28(10): 739-748.
[3]	Qin Yang, Dong Li, Chao Feng, Yi Fan, Hua Li, Quan Du. Genome-wide identification of long noncoding RNAs in myocyte differentiation [J]. Journal of Chinese Pharmaceutical Sciences, 2017, 26(6): 423-431.
[4]	Min Feng, Jinxia Li, Xiaojie Ma,Yunzhou Fan, Jingxuan Wu, Qun Zeng, Xiaogai Yang. The involvement of signaling activation of protein kinase C in gadolinium chloride-induced cell survival and cell cycle progression in NIH3T3 cells [J]. Journal of Chinese Pharmaceutical Sciences, 2014, 23(11): 772-777.
[5]	Lijia Yuan, Cong Wang, Wei Liu, Wenlong Liu, Baodi Gou, Tianlan Zhang . Realgar induces differentiation through ROS-dependent mitochondrial pathway in HL-60 cells [J]. , 2013, 22(2): 184-189.
[6]	Xin Pan, Jinxia Li, Faqin Dong, Jianjun Deng, Lan Yuan, Kui Wang, Siwang Yu^*. Lanthanum chloride promotes proliferation of NIH 3T3 cells via cell cycle machinery [J]. , 2013, 22(1): 64-70.
[7]	Xiao Wan, Baodi Gou^, Kui Wang^. Gadolinium-promoted angiogenesis involves the activation of PKCα/β2 and MAPKs in human umbilical vein endothelial cells [J]. , 2013, 22(1): 71-76.
[8]	Yong-Jun Liu, Zhi-Jin Chen, Na Zhang^* . Novel nanovectors as liver targeting MRI contrast agents [J]. , 2011, 20(2): 105-117.
[9]	CUI Jing-rong, HUI Yu, XIANG You-qing, ZHANG Li-he^*. Effect of 8-Chloroadenosine on Undifferentiatied HL-60 Cell Line [J]. , 2003, 12(4): 215-221.
[10]	Zong-Ru Guo, Quan-Zhi Liu, Min-Min Wang. Study on the Equivalent Conformation of Retinoids [J]. , 1997, 6(4): 173-177.
[11]	Qi Wu^*, Dian-Dong Li, Yong-Su Zhen. Induction of Erythroid Differentiation of HumanErythroleukemia K-562 Cells by Mutactimycin [J]. , 1995, 4(2): 82-88.
[12]	Hui-Chen Liu, De-Zheng Wu. Induction-Differentiation Effectof β-Caroteneon Human Promyelocytic Leukemia Cells [J]. , 1994, 3(1): 81-84.