Abstract:

Chemical constituents of the whole herb of Rhodiola kirilowii (Regl) Maxim. were investigated. The separation of the constituents was achieved by using a combination of various chromatographic techniques including column chromatography over silica gel, ODS, Sephadex LH-20 and reversed-phase HPLC. Their structures were elucidated by spectroscopic techniques including 1D and 2D NMR spectroscopy. Eleven compounds were obtained and identified as 4-[2-[(4-methoxyphenyl)ethoxy]ethyl]phenol (1), 1-(2-hydroxy-2-methylbutanoate)-β-D-glucopyranose (2), 4-ethoxy-phenylethanol acetate (3), p-hydroxyacetophenone (4), p-hydroxy-benzoic acid ethylester (5), 4-hydroxybenzoic acid (6), 4-hydroxybenzaldehyde (7), R(-)-mellein (8), stigmasterol (9), 4-methoxy-phenylethanol (10), and methylgallate (11). Among them, 1 and 2 are new compounds; compounds 3, 5, 7, 8, and 10 were isolated from Rhodiola genus for the first time; and compounds 4, 6, 9, and 11 were isolated from Rhodiola kirilowii (Reg1) Maxim. for the first time.

Key words: Rhodiola kirilowii, Chemical constituents, Structural identification

CLC Number: 

• R284.2

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