药物由骨架型透皮给药装置中扩散－溶出控释的简单表达式

药物由骨架型透皮给药装置中扩散－溶出控释的简单表达式

郑俊民, 杨丽, 何友清

沈阳药科大学药剂教研室, 沈阳 110015

收稿日期:1993-12-08 修回日期:1994-09-05 出版日期:1995-09-15 发布日期:1995-09-15

A Simplified Expression for a Diffusion-Dissolution Controlled Release of Drug from Matrix in TDDS

Jun-Min Zheng, Li Yang, You-Qing He

Department of Pharmaceulics; Shenyang Pharmaceutical University; Shenyang 110015

Received:1993-12-08 Revised:1994-09-05 Online:1995-09-15 Published:1995-09-15

摘要/Abstract

摘要： Chandrasekran-paul (1982) made an equation of drug release from matrix system as follows: In this paper a simplified expression has been deduced from it within ordinary range of experimental time and with appropriate values of K. The cumulative amount of drug release may vary in directproportion to the square root of time with an intercept, that is, The release behaviour of both nifedipine patch and propranolol patch has fit the expression with good correlation coefficient.The re0lease data of hydrocortisone creams (Shah, 1989)also can be described by the same expression.Compared with Higuchi’s equation, the presence of the intercept, A'', may be relative to drug dissolution characteristics.

关键词: Higuchi方程, Chandrasekran-Paul方程, 药物由透皮给药装置骨架中的释放

Abstract: Chandrasekran-paul (1982)对药物由骨架系统中的释放, 提出下列表达式: 本文在常见的实验时间及适当的K值范围内对上式作了简化, 药物释放的累积量与时间的平方根直接成比例, 但方程中带有一截距项, 即, 硝苯地平贴剂及普萘洛尔贴剂二者的释放行为都符合上述方程, 其相关系数良好。氢化可的松乳膏的释放数据(据Shah, 1989), 也可用相同的方程来描述。该方程与Higuchi方程相比较, 多出一个截距项, 这可能与药物溶出特性有关。