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小檗胺对小鼠迟发型超敏反应的影响

林新, 罗崇念, 冯璞, 刘淑香, 王立为, 谢蜀生, 肖培根   

  1. 1. 中国医学科学院 中国协和医科大学药用植物研究所免疫室, 北京 100094;
    2. 北京医科大学免疫研究中心, 北京 100083
  • 收稿日期:1996-11-08 修回日期:1997-10-10 出版日期:1998-03-15 发布日期:1998-03-15

Inhibitory Actions of Berbamine on Delayed-type Hypersensitivity in Mice

Xin Lin, Chong-Nian Luo, Pu Feng, Shu-Xiang Liu, Li-Wei Wang, Shu-Sheng Xie, Pei-Gen Xiao   

  1. 1. Department of Immunology, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100094;
    2. Research Center for Immunology, Beijing Medical University, Beijing 100083
  • Received:1996-11-08 Revised:1997-10-10 Online:1998-03-15 Published:1998-03-15

摘要: 本文研究了小檗胺对小鼠由绵羊红细胞, 二硝基氯苯及同种异型脾细胞所诱导的迟发型超敏反应的影响。实验结果显示小檗胺能明显抑制小鼠的迟发型超敏反应, 表明小檗胺可能对小鼠的细胞免疫功能具有抑制作用。

关键词: 小檗胺, 迟发型超敏反应, 细胞免疫, 小鼠

Abstract: The action of berbamine on murine delayed-type hypersensitivity (DTH) reaction induced by sheep red blood cells (SRBC), 2,4-dinitrochlorobenzene, and allotypic splenocytes was studied. The results show that berbamine can inhibit the DTH reaction significantly. It is concluded that berbamine may inhibit cell mediated immunity in mice.

Key words: Berbamine, Delayed-type hypersensitivity, Cell mediated immunity, Mice

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