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20(R)-人参皂甙Rg3人体药代动力学研究

庞焕, 汪海林, 富力, 苏成业   

  1. 1.大连医科大学药理教研室, 大连 116027;
    2.中国科学院大连化学物理研究所国家色谱研究分析中心, 大连 116011;
    3.大连天富科技开发有限公司天然药物研究所, 大连 116600
  • 收稿日期:2001-05-05 修回日期:2001-06-21 出版日期:2001-09-15 发布日期:2001-09-15

Pharmacokinetics of 20(R)-Ginsenoside Rg3 in Human Volunteers

Pang Huan, Wang Hailin, Fu Li, Su Chengye   

  1. 1. Department of Pharmacology, Dalian Medical University, Dalian 116027;
    2. National Chromatographic R & A Center of China, Dalian Institute of Chemical and Physics, Academia Sinica, Dalian 116011;
    3. Institute of Natural Pharmacy, Dalian Tianfu Scienctific and Technological Limited Corporation, Dalian 116600
  • Received:2001-05-05 Revised:2001-06-21 Online:2001-09-15 Published:2001-09-15

摘要: 目的: 研究20(R)-人参皂甙Rg3人体药代动力学。方法: 高效液相色谱-紫外检测法。结果: 8名健康志愿者单剂量口服3.2 mg·kg-1 20(R)-人参皂甙Rg3, 其药时曲线符合口服吸收有滞后时间的二房室模型, Tmax0.66±0.10 h, Cmax166 ng·mL-1, T1/2α0.46±0.12 h, T1/2β4.9±1.1 h, T1/2(Ka) 0.28±0.04 h, AUC0-77±26 ng·mL-1·h; 6名健康志愿者单剂量口服0.8 mg·kg-1 Rg3, 由于血药浓度低, 可测数据点少, 未进行模型模拟; 两组给药剂量与相应Cmax实测值比较, 二者成正比关系。结论: 本品口服吸收快, 消除也较快, 但血药浓度很低。在所试剂量范围内, 20(R)-人参皂甙Rg3属一级动力学吸收﹑消除过程。

关键词: 20R-人参皂甙Rg3, 高效液相色谱法, 药代动力学, 人体

Abstract: Objective: To study the pharmacokinetics of 20(R)-Ginsenoside Rg3 in the human body. Methods: High-performance liquid chromatography-ultraviolet detection method was used in this study. Results: The pharmacokinetics of Ginsenoside Rg3 in 14 healthy volunteers were investigated. After a single oral dose of 3.2 mg·kg-1 Ginsenoside Rg3 in 8 male volunteers, the plasma concentration-time course fitted in well with a two-compartment open model, with the following pharmacokinetic parameters: Tmax 0.66±0.10 h, Cmax 166 ng·mL-1, T1/2α 0.46±0.12 h, T1/2β 4.9±1.1 h, T1/2(Ka) 0.28±0.04 h, AUC0- 7726 ng·mL-1·h, respectively. No kinetic analysis was made after an oral dose of 0.8 mg·kg-1 Rg3 in other 6 volunteers because of the low concentration, but there was a good correlation between Cmax and dosage of the two groups. Conclusion: The absorption of Rg3 was rapid in the human body, and its elimination was rapid too after oral administration of Ginsenoside Rg3. The pharmacokinetic results shows that it exhibited the first-order kinetic characteristics.

Key words: 20R-Ginsenoside Rg3, HPLC, Pharmacokinetics, Human

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