中药墨旱莲中的三萜皂苷

中药墨旱莲中的三萜皂苷

汤海峰, 赵越平, 蒋永培, 王忠壮, 易杨华, 雷其云

1.第四军医大学西京医院药剂科, 西安 710032;
2.第二军医大学长海医院, 上海 200433;
3.第二军医大学药学院, 上海 200433

收稿日期:2001-10-20 修回日期:2001-11-02 出版日期:2001-12-15 发布日期:2001-12-15

Triterpenoid Saponins from Eclipta prostrata L.

Tang Haifeng, Zhao Yueping, Jiang Yongpei, Wang Zhongzhuang, Yi Yanghua, Lei Qiyun

1. Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an 710032;
2. Changhai Hospital, Second Military Medical University, Shanghai 200433;
3. College of Pharmacy, Second Military Medical University, Shanghai 200433

Received:2001-10-20 Revised:2001-11-02 Online:2001-12-15 Published:2001-12-15

摘要/Abstract

摘要： 从中药墨旱莲Eclipta prostrata L. 中分离得到5个三萜皂苷,根据理化性质和光谱数据,分别鉴定为eclalbasaponins II (1), I (2), III (3), 3-O-[β-D-吡喃葡糖(12)-β-D-吡喃葡糖]-16α-乙氧基-齐墩果酸-28-O-β-D-吡喃葡糖苷(4) 和3-O-[(2-O-硫酰基-β-D-吡喃葡糖)(12)- β-D-吡喃葡糖]-刺囊酸-28-O-β-D-吡喃葡糖苷(5)。化合物4 和5 为新化合物,分别命名为eclalbasaponins XI 和eclalbasaponins XII。化合物1 和5 具有诱导稻瘟霉菌丝变形活性。

关键词: 墨旱莲, Eclalbasaponin XI, Eclalbasaponins XII, 稻瘟霉, 活性测试

Abstract: Five triterpenoid saponins were isolated from the Chinese traditional medicine Eclipta prostrata L.. On the basis of their chemical properties and spectral data, they were identified as eclalbasaponins II(1), I(2), III(3), 3-O-[β-D-glucopyranosyl(12)-β-D-glucopyranosyl]-16α-ethoxy-olean-12-ene-28-oic acid-28-O-β-D-glu-copyranoside(4) and 3-O-[(2-O-sulfuryl-β-D-glucopyranosyl)(12)-β-D-glucopyranosyl]-echinocystic acid-28-O-β-D-glucopyranoside(5). Compounds 4 and 5 are new compounds and named eclalbasaponins XI and XII, respectively. Compounds 1 and 5 induced morphological deformation of Pyricularia oryzae mycelia.

Key words: Eclipta prostrata, Eclipta prostrata, Eclalbasaponin XI, Eclalbasaponin XI, Eclalbasaponin XII, Eclalbasaponin XII, Pyricularia oryzae, Pyricularia oryzae, Bioassay, Bioassay

Supporting:

^*First published in Chinese in Acta Pharmaceutica Acta, 2001, 36: 660.

汤海峰, 赵越平, 蒋永培, 王忠壮, 易杨华, 雷其云. 中药墨旱莲中的三萜皂苷[J]. .

Tang Haifeng, Zhao Yueping, Jiang Yongpei, Wang Zhongzhuang, Yi Yanghua, Lei Qiyun. Triterpenoid Saponins from Eclipta prostrata L.[J]. .