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1H NMR研究含有二糖结构的核苷类似物构型

刘仲杰, 崔育新*, 刘雪辉, 闵吉梅, 张礼和   

  1. 北京医科大学天然药物及仿生药物国家重点实验室, 北京 100083
  • 收稿日期:1999-04-08 修回日期:1999-08-06 出版日期:2000-03-15 发布日期:2000-03-15
  • 通讯作者: 崔育新*

Study on the Configuration of Nucleoside Analogues Containing Disaccharide by 1H NMR

Liu Zhongjie, Cui Yuxin*, Liu Xuehui, Min Jimei, Zhang Lihe   

  1. National Research Laboratory of Natural and Biomimetic Drugs, Beijing Medical University, Beijing 100083
  • Received:1999-04-08 Revised:1999-08-06 Online:2000-03-15 Published:2000-03-15
  • Contact: Cui Yuxin*

摘要: 利用Ferrier反应, 合成了一类新的含有二糖结构的核苷类似物。通过GCOSYGNOESY技术归属了所有的质子, 并讨论了这类化合物的构型。所得结论与计算机分子模拟结果一致。

关键词: Ferrier反应, 核苷类似物, 1H NMR

Abstract: A new kind of nucleoside analogues containing disaccharide resulting from Ferrier reaction of glycal was synthesized. Their (a, b, c, d) 1H NMR signals were assigned by GCOSY and GNOESY, the configuration was also determined. The results are in accord with computer-aided molecular simulation.

Key words: Ferrier reaction, Ferrier reaction, Nucleoside analogues, Nucleoside analogues, 1H NMR, 1H NMR

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