关键词: 糖, 肿瘤相关抗原, STn, 合成

Abstract: Modified tumor-associated carbohydrate antigens could be used to develop anti-cancer vaccines. Carbohydrate antigens in which thioglycosidic linkages are used instead of O-glycosidic linkages may be more immunogenic and may stimulate the production of antibodies capable of recognizing naturally occurring carbohydrates due to their enhanced resistance to endogenous glycosidases and their inherent non-self antigen character. For this purpose, a new S-linked tumor-associated carbohydrate antigen STn has been successfully synthesized for the first time.

Key words: Carbohydrate, Carbohydrate, Tumor-associated antigen, Tumor-associated antigen, STn, STn, Synthesis, Synthesis