聚(甲基丙烯酸-co-泊洛沙姆)水凝胶的溶胀和药物释放性质

聚(甲基丙烯酸-co-泊洛沙姆)水凝胶的溶胀和药物释放性质

徐晖^*, 林燕喃, 丁平田, 田美娟, 郑俊民

沈阳药科大学药学院, 沈阳 110016

收稿日期:2003-04-12 修回日期:2003-11-10 出版日期:2003-12-15 发布日期:2003-12-15
通讯作者: 徐晖*

Swelling and Drug Release Characteristics of Poly (methacrylic acid-co-poloxamer) hydrogels

XU Hui^*, LIN Yan-nan, DING Ping-tian, TIAN Mei-juan, ZHENG Jun-min

School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China

Received:2003-04-12 Revised:2003-11-10 Online:2003-12-15 Published:2003-12-15
Contact: XU Hui*

摘要/Abstract

摘要： 以自由基溶液聚合方法制备了聚(甲基丙烯酸-co-泊洛沙姆)共聚物水凝胶, 研究凝胶的溶胀和模型药物氢溴酸右美沙芬(DMP)和维生素B12的释放性质. 凝胶的溶胀和药物释放具有pH-依赖的特征, 在中性或碱性介质中的溶胀和药物释放速率要高于酸性介质中. 在中性或碱性介质中, 凝胶的溶胀为非Fick或零级过程, 对于组成适当的水凝胶, 在数小时内以零级动力学过程释放药物.

关键词: 甲基丙烯酸, 泊洛沙姆, pH-依赖型水凝胶, 溶胀, 药物释放

Abstract: Poly (methacrylic acid co-poloxamer) hydrogel networks were synthesized by free-radical solution polyme-rization, and the dynamic swelling and in vitro release properties of model drugs, dextromethorphan hydrobromide (DMP) and vitamin B12 (VB12) were studied. These gels exhibited pH-dependant swelling and sustained drug release properties, and the water uptake rate and drug release rate in neutral or basic media were higher than that in acidic media. The results showed that the water uptake followed non-Fickian or zero order process in neutral or basic media, and the release of model drugs from hydrogels of appropriate composition was of zero order kinetics over a period of several hours.

Key words: methacrylic acid, methacrylic acid, poloxamer, poloxamer, pH dependent hydrogel, pH dependent hydrogel, swelling, swelling, drug release, drug release

中图分类号:

R917.75

R944.15

Supporting:

徐晖^*, 林燕喃, 丁平田, 田美娟, 郑俊民. 聚(甲基丙烯酸-co-泊洛沙姆)水凝胶的溶胀和药物释放性质[J]. .

XU Hui^*, LIN Yan-nan, DING Ping-tian, TIAN Mei-juan, ZHENG Jun-min. Swelling and Drug Release Characteristics of Poly (methacrylic acid-co-poloxamer) hydrogels[J]. .

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