曾克武/屠鹏飞团队揭示高三尖杉酯碱抗白血病分子新靶点

中国药学(英文版) ›› 2025, Vol. 34 ›› Issue (12): 1145-1145.

曾克武/屠鹏飞团队揭示高三尖杉酯碱抗白血病分子新靶点

北京大学药学院天然药物及仿生药物全国重点实验室

北京大学药学院天然药物及仿生药物全国重点实验室

收稿日期:2025-11-20 修回日期:2025-11-20 接受日期:2025-11-20 出版日期:2025-12-31 发布日期:2025-12-31

The team of Prof. Kewu Zeng and Prof. Pengfei Tu has revealed a new molecular target of homoharringtonine for anti-leukemia

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center

Received:2025-11-20 Revised:2025-11-20 Accepted:2025-11-20 Online:2025-12-31 Published:2025-12-31

摘要/Abstract

摘要：

近日, 北京大学药学院天然药物及仿生药物全国重点实验室曾克武与屠鹏飞团队在国际学术期刊iMeta上发表了题为“Homoharringtonine suppresses acute myeloid leukemia progression by orchestrating EWSR1 phase separation in an m⁶A-YTHDF2-dependent mechanism”的研究论文, 揭示了抗白血病天然药物高三尖杉酯碱(Homoharringtonine, HHT)通过诱导EWSR1蛋白发生液-液相分离, 进而调控m⁶A-YTHDF2通路, 抑制急性髓系白血病(AML)进展的全新作用机制。

Supporting:

北京大学药学院天然药物及仿生药物全国重点实验室. 曾克武/屠鹏飞团队揭示高三尖杉酯碱抗白血病分子新靶点[J]. 中国药学(英文版), 2025, 34(12): 1145-1145.

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center. The team of Prof. Kewu Zeng and Prof. Pengfei Tu has revealed a new molecular target of homoharringtonine for anti-leukemia[J]. Journal of Chinese Pharmaceutical Sciences, 2025, 34(12): 1145-1145.