摘要：
2025年5月14日, 北京大学药学院天然药物及仿生药物全国重点实验室马明课题组在Nature Chemistry上发表了题为 “Structural insights into two thiamine diphosphate-dependent enzymes and their synthetic applications in carbon–carbon linkage reactions”的研究论文。该研究首次阐明了一类催化分子间碳-碳键连接反应的ThDP-依赖酶的晶体结构、底物选择性和立体选择性机制, 并通过酶的理性改造和酶法全合成制备了大量碳-碳键连接化合物。
Supporting:
北京大学药学院天然药物及仿生药物全国重点实验室. 马明团队解析新颖ThDP-依赖酶结构并酶法制备碳-碳键连接化合物[J]. 中国药学(英文版), 2025, 34(6): 596-601.
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center. The research team of Prof. Ming Ma analyzed the novel THDP-dependent enzyme structure and prepared carbon-carbon bond-linkage compounds by enzymatic method[J]. Journal of Chinese Pharmaceutical Sciences, 2025, 34(6): 596-601.
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