2009–2023年世界范围内蛇毒解离素的文献计量学研究

doi:10.5246/jcps.2024.11.073

中国药学(英文版) ›› 2024, Vol. 33 ›› Issue (11): 1012-1024.DOI: 10.5246/jcps.2024.11.073

2009–2023年世界范围内蛇毒解离素的文献计量学研究

蓝荫香¹^,^*(), 邱秀梁², 黄丹丹¹

^1. 福建省儿童医院 (上海儿童医学中心福建医院) 药剂科, 福建医科大学妇儿临床医学院, 福建福州 350000
^2. 福建省肿瘤医院药剂科, 福建福州 350014

收稿日期:2024-02-14 修回日期:2024-03-25 接受日期:2024-05-12 出版日期:2024-12-10 发布日期:2024-12-10
通讯作者: 蓝荫香

Bibliometric and visual analysis of global research on snake venom disintegrins (2009–2023)

Yinxiang Lan¹^,^*(), Xiuliang Qiu², Dandan Huang¹

¹ Department of Pharmacy, Fujian Children’s Hospital (Fujian Branch of Shanghai Children’s Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350000, Fujian, China
² Department of Pharmacy, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, Fujian, China

Received:2024-02-14 Revised:2024-03-25 Accepted:2024-05-12 Online:2024-12-10 Published:2024-12-10
Contact: Yinxiang Lan
Supported by:
Startup Fund for Scientific Research, Fujian Medical University (Grant No. 2022QH1216).

摘要/Abstract

摘要：

蛇毒解离素通过阻止与整合素的结合, 抑制细胞-细胞、细胞-基质相互作用和信号转导, 可能成为多种疾病的先导治疗药物。本研究旨在对近年来蛇毒解离素的研究热点进行文献计量学分析。本文使用相关关键词检索Web of Science Core Collection (WOSCC)数据库, 使用CiteSpace和VOSviewer进行分析。我们纳入了2009年至2023年间发表的142篇文献, 这些文献由来自42个国家207个研究所的670位作者发表在74种期刊上。美国发表最多篇, 得克萨斯农工大学是发表最多论文的组织。Elda E. Sanchez是主要作者, 《毒素》是发表论文最多的杂志。关键词分析表明, 该领域的研究趋势主要集中在表达、体外和含ASP肽方面。本研究为2009–2023年全球蛇毒解离素的研究提供了有价值的分析, 并为未来的研究方向提供了参考。本研究揭示了当前解离素的研究热点, 这些结果可以为进一步的研究提供重要的方向。

关键词: 蛇毒解离素, 文献计量分析, CiteSpace, VOSviewer, 研究趋势

Abstract:

Snake venom disintegrins, through their inhibition of integrin-related binding, effectively impede both cell-cell and cell-matrix interactions as well as signal transduction pathways, rendering them promising candidates for lead therapeutics across a spectrum of diseases. This study aimed to conduct a comprehensive bibliometric analysis, elucidating recent trends in disintegrin research. Using relevant keywords, we meticulously explored the Web of Science Core Collection (WOSCC) database. Employing CiteSpace and VOSviewer, we conducted an exhaustive analysis, encompassing 142 documents published between 2009 and 2023. These publications, dispersed across 74 journals, involved 670 authors representing 207 institutes spanning 42 countries. Notably, the United States contributed the highest number of records, with Texas A&M University emerging as the most prolific institution. Within this landscape, Elda E. Sanchez emerged as the foremost author, and Toxicon emerged as the predominant journal. Keyword analysis underscored prevailing research foci, with an emphasis on expression, in vitro experimentation, and ASP-containing peptides. This study presented a comprehensive overview of disintegrin research globally, spanning the period from 2009 to 2023, and held potential utility in guiding future research endeavors. By identifying current research hotspots, our findings offered invaluable insights to shape forthcoming investigations in this dynamic field.

Key words: Snake venom disintegrins, Biblimetric analysis, CiteSpace, VOSviewer, Research trends

Supporting:

蓝荫香, 邱秀梁, 黄丹丹. 2009–2023年世界范围内蛇毒解离素的文献计量学研究[J]. 中国药学(英文版), 2024, 33(11): 1012-1024.

Yinxiang Lan, Xiuliang Qiu, Dandan Huang. Bibliometric and visual analysis of global research on snake venom disintegrins (2009–2023)[J]. Journal of Chinese Pharmaceutical Sciences, 2024, 33(11): 1012-1024.

图/表 18

Figure 1. Flowchart of systematic literature search.

Figure 2. Distribution of publications.

Figure 3. The country collaboration network.

Table 1. The top nine most productive countries.

Table 2. The top 10 productive organizations.

Figure 4. Institution density map.

Figure 5. Distribution of authors. (A) The network map of the authors; (B) The network of co-cited authors.

Table 3. The top five authors by number of publications.

Table 4. The top five citation journals.

Figure 6. Visualisation of journals. (A) Density map of cited journals; (B) Density map of co-cited journals.

Table 5. The top five co-citation journals.

Figure 7. Network cluster of co-cited literature.

Table 6. The top five co-cited articles on disintegrin-related research.

Figure 8. Keyword co-occurrence map.

Table 7. The top 20 keyword co-occurrence.

Figure 9. Visualization of keyword burst.

Figure 10. Keyword cluster analysis.

Figure 11. Timeline view of keyword clusters.

参考文献 31

[1]	Lazarovici, P.; Marcinkiewicz, C.; Lelkes, P.I. From snake venom’s disintegrins and C-type lectins to anti-platelet drugs. Toxins. 2019, 11, 303.
[2]	Vasconcelos, A.A.; Estrada, J.C.; Caruso, I.P.; Kurtenbach, E.; Zingali, R.B.; Almeida, F.C.L. Toward the mechanism of jarastatin (rJast) inhibition of the integrin αVβ3. Int. J. Biol. Macromol. 2024, 255, 128078.
[3]	Lucena, S.E.; Romo, K.; Suntravat, M.; Sánchez, E.E. Anti-angiogenic activities of two recombinant disintegrins derived from the Mohave and Prairie rattlesnakes. Toxicon. 2014, 78, 10–17.
[4]	Kuo, Y.J.; Chung, C.H.; Huang, T.F. From discovery of snake venom disintegrins to A safer therapeutic antithrombotic agent. Toxins. 2019, 11, 372.
[5]	Liu, S.C.; Sun, Y.; Zhang, T.; Cao, L.T.; Zhong, Z.W.; Cheng, H.X.; Wang, Q.Q.; Qiu, Z.; Zhou, W.M.; Wang, X.L. Upconversion nanoparticles regulated drug & gas dual-effective nanoplatform for the targeting cooperated therapy of thrombus and anticoagulation. Bioact. Mater. 2022, 18, 91–103.
[6]	Sanchez, E.F.; Flores-Ortiz, R.J.; Alvarenga, V.G.; Eble, J.A. Direct fibrinolytic snake venom metalloproteinases affecting hemostasis: structural, biochemical features and therapeutic potential. Toxins. 2017, 9, 392.
[7]	Arruda Macêdo, J.K.; Fox, J.W.; de Souza Castro, M. Disintegrins from snake venoms and their applications in cancer research and therapy. Curr. Protein Pept. Sci. 2015, 16, 532–548.
[8]	Lucena, S.; Rodríguez-Acosta, A.; Grilli, E.; Alfonso, A.; Goins, A.; Ogbata, I.; Walls, R.; Suntravat, M.; Uzcátegui, N.L.; Guerrero, B.; Sánchez, E.E. The characterization of trans-Pecos copperhead (Agkistrodon contortrix pictigaster) venom and isolation of two new dimeric disintegrins. Biologicals. 2016, 44, 191–197.
[9]	Vasconcelos, A.A.; Estrada, J.C.; David, V.; Wermelinger, L.S.; Almeida, F.C.L.; Zingali, R.B. Structure-function relationship of the disintegrin family: sequence signature and integrin interaction. Front. Mol. Biosci. 2021, 8, 783301.
[10]	Cesar, P.H.S.; Braga, M.A.; Trento, M.V.C.; Menaldo, D.L.; Marcussi, S. Snake venom disintegrins: an overview of their interaction with integrins. Curr. Drug Targets. 2019, 20, 465–477.
[11]	Zhang, Y.; Lu, L.; Zheng, R. Emerging trends and focus on immune checkpoint inhibitors for non-small cell lung cancer treatment: visualization and bibliometric analysis. Frontiers in pharmacology. 2023, 14, 1140771.
[12]	Zhang, M.; Kou, L.; Qin, Y.Y.; Chen, J.W.; Bai, D.Z.; Zhao, L.; Lin, H.Y.; Jiang, G.H. A bibliometric analysis of the recent advances in diazepam from 2012 to 2021. Front. Pharmacol. 2022, 13, 1042594.
[13]	Guo, J.S.; Wang, H.; Li, Y.; Zhu, S.; Hu, H.X.; Gu, Z.J. Nanotechnology in coronary heart disease. Acta Biomater. 2023, 171, 37–67.
[14]	Wang, Q.; Yang, K.L.; Zhang, Z.; Wang, Z.; Li, C.; Li, L.; Tian, J.H.; Ye, Y.J.; Wang, S.; Jiang, K.W. Characterization of global research trends and prospects on single-cell sequencing technology: bibliometric analysis. J. Med. Internet Res. 2021, 23, e25789.
[15]	Wang, Y.; Rao, Y.F.; Lin, Z.J.; Sa, R.N.; Yin, Y.L.; Zhang, X.M.; Zhang, B. Current status and trends of research on anthracycline-induced cardiotoxicity from 2002 to 2021: a twenty-year bibliometric and visualization analysis. Oxid. Med. Cell Longev. 2022, 2022, 6260243.
[16]	Sabe, M.; Chen, C.M.; Perez, N.; Solmi, M.; Mucci, A.; Galderisi, S.; Strauss, G.P.; Kaiser, S. Thirty years of research on negative symptoms of schizophrenia: a scientometric analysis of hotspots, bursts, and research trends. Neurosci. Biobehav. Rev. 2023, 144, 104979.
[17]	Ling, L.X.; Ouyang, Y.B.; Hu, Y. Research trends on nanomaterials in gastric cancer: a bibliometric analysis from 2004 to 2023. J. Nanobiotechnol. 2023, 21, 248.
[18]	Zhao, J.; Liao, B.; Gong, L.; Yang, H.Y.; Li, S.; Li, Y.S. Knowledge mapping of therapeutic cancer vaccine from 2013 to 2022: a bibliometric and visual analysis. Hum. Vaccin. Immunother. 2023, 19, 2254262.
[19]	Yu, Z.Y.; Xie, L.; Zhang, J.; Lin, H.; Niu, T. The evolution of minimal residual disease: key insights based on a bibliometric visualization analysis from 2002 to 2022. Front. Oncol. 2023, 13, 1186198.
[20]	Guo, Y.; Zhang, H.Q.; Yu, X.Q. A bibliometric analysis of complement in IgA nephropathy from 1991 to 2022. Front. Pharmacol. 2023, 14, 1200193.
[21]	Zhang, Y.; Liu, X.Y.; Qiao, X.F.; Fan, Y.B. Characteristics and emerging trends in research on rehabilitation robots from 2001 to 2020: bibliometric study. J. Med. Internet Res. 2023, 25, e42901.
[22]	Yang, X.L.; Yin, H.; Zhang, D.Y.; Peng, L.S.; Li, K.L.; Cui, F.; Xia, C.C.; Li, Z.S.; Huang, H.J. Bibliometric analysis of cathepsin B research from 2011 to 2021. Frontiers in medicine, 2022, 9, 898455.
[23]	Li, F.C.; Zhang, D.; Li, Z.; Hou, Z.M.; Chen, W.; Chen, J.; Hu, Y.Q. Exploring the landscape of stem cell research for Alzheimer’s disease: a bibliometric analysis spanning 2002–2021. J. Chin. Pharm. Sci. 2023, 32, 813.
[24]	Sofyantoro, F.; Yudha, D.S.; Lischer, K.; Nuringtyas, T.R.; Putri, W.A.; Kusuma, W.A.; Purwestri, Y.A.; Swasono, R.T. Bibliometric analysis of literature in snake venom-related research worldwide (1933-2022). Anim. Basel. 2022, 12, 2058.
[25]	Succar, B.B.; Saldanha-Gama, R.F.G.; Valle, A.S.; Wermelinger, L.S.; Barja-Fidalgo, C.; Kurtenbach, E.; Zingali, R.B. The recombinant disintegrin, jarastatin, inhibits platelet adhesion and endothelial cell migration. Toxicon. 2022, 217, 87–95.
[26]	Seo, M.J. ;Choi, H.J.;Chung, K.H.Pyun, Y.R. Production of a platelet aggregation inhibitor, salmosin, by high cell density fermentation of recombinant escherichia coli. J. Microbiol. Biotechnol. 2011, 21, 1053–1056.
[27]	Danilucci, T.M.; Santos, P.K.; Pachane, B.C.; Pisani, G.F.D.; Lino, R.L.B.; Casali, B.C.; Altei, W.F.; Selistre-de-Araujo, H.S. Recombinant RGD-disintegrin DisBa-01 blocks integrin αvβ3 and impairs VEGF signaling in endothelial cells. Cell Commun. Signal. 2019, 17, 27.
[28]	Higuchi, D.A.; Almeida, M.C.; Barros, C.C.; Sanchez, E.F.; Pesquero, P.R.; Lang, E.A.S.; Samaan, M.; Araujo, R.C.; Pesquero, J.B.; Pesquero, J.L. Leucurogin, a new recombinant disintegrin cloned from Bothrops leucurus (white-tailed-jararaca) with potent activity upon platelet aggregation and tumor growth. Toxicon. 2011, 58, 123–129.
[29]	David, V.; Succar, B.B.; de Moraes, J.A.; Saldanha-Gama, R.F.G.; Barja-Fidalgo, C.; Zingali, R.B. Recombinant and chimeric disintegrins in preclinical research. Toxins. 2018, 10, 321.
[30]	Kolvekar, N.; Bhattacharya, N.; Sarkar, A.; Chakrabarty, D. How snake venom disintegrins affect platelet aggregation and cancer proliferation. Toxicon. 2023, 221, 106982.
[31]	Akhtar, B.; Muhammad, F.; Sharif, A.; Anwar, M.I. Mechanistic insights of snake venom disintegrins in cancer treatment. Eur. J. Pharmacol. 2021, 899, 174022.

2009–2023年世界范围内蛇毒解离素的文献计量学研究

Bibliometric and visual analysis of global research on snake venom disintegrins (2009–2023)

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

图/表 18

参考文献 31

相关文章 3

编辑推荐

Metrics

本文评价

[1]	卢晓静, 贾雪冬, 司方莹, 杨晰, 张婉, 尹钊. 药师主导的老年患者干预研究: 一项文献计量学分析[J]. 中国药学(英文版), 2024, 33(8): 751-765.
[2]	彭紫凝, 邓茜, 孟凡雨, 王兴强, 刘念, 晏蔚田, 彭江云. 通过文献计量学方法分析痛风和高尿酸血症动物模型的研究现状[J]. 中国药学(英文版), 2024, 33(11): 1058-1067.
[3]	李哲, 罗晓岁, Abid Naeem, 李琼, 张尧, 管咏梅, 陈丽华, 朱卫丰, 金正吉, 冯怡, 明良山. 固体制剂物理结构的研究进展[J]. 中国药学(英文版), 2024, 33(10): 877-905.