深海真菌Aspergillus versicolor F77的次级代谢产物

doi:10.5246/jcps.2021.01.004

中国药学(英文版) ›› 2021, Vol. 30 ›› Issue (1): 42-48.DOI: 10.5246/jcps.2021.01.004

深海真菌Aspergillus versicolor F77的次级代谢产物

康颖, 张婵娟, 张贺, 刘东^*()

北京大学医学部药学院天然药物及仿生药物国家重点实验室, 北京 100191

收稿日期:2020-06-19 修回日期:2020-09-10 接受日期:2020-09-18 出版日期:2021-01-29 发布日期:2021-01-29
通讯作者: 刘东
作者简介:
+ Tel.: +86-10-82805771, E-mail: liudong_1982@126.com
基金资助:
Beijing Natural Science Foundation (Grant No. 7182086).

Secondary metabolites from a deep-sea-derived Aspergillus versicolor F77

Ying Kang, Chanjuan Zhang, He Zhang, Dong Liu^*()

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China

Received:2020-06-19 Revised:2020-09-10 Accepted:2020-09-18 Online:2021-01-29 Published:2021-01-29
Contact: Dong Liu

摘要/Abstract

摘要：

运用多种色谱和波谱技术从深海真菌Aspergillus versicolor F77的发酵提取物中分离鉴定了2个新化合物acetyl-sydonol (1)和hydroxy-diorcinol D (2), 1个新天然产物1-(2,4-dimethoxyphenyl)-1,2-dihydro-3H-pyrazol-3-one (3), 以及4个已知化合物sydonol (4), (S)-sydonic acid (5), aspergillusene A (6)和diorcinol D (7)。利用多种波谱学方法并结合文献数据比对确定了化合物的化学结构, 化合物6具有一定的抑制NF-κB活性。

关键词: 深海真菌, Aspergillus versicolor, 次级代谢产物, NF-κB抑制活性

Abstract:

Chemical examination of fermentation products of a deep-sea-derived fungus Aspergillus versicolor F77 led to the isolation of two new compounds acetyl-sydonol (1) and 2-hydroxydiorcinol D (2), a new natural product 1-(2,4-dimethoxyphenyl)-1,2-dihydro-3H-pyrazol-3-one (3), together with four known compounds sydonol (4), (S)-sydonic acid (5), aspergillusene A (6) and diorcinol D (7). Their structures were determined through the extensive spectroscopic analysis and comparison with the reported data in literature. Compound 6 showed moderate NF-κB inhibitory activity.

Key words: Deep-sea-derived fungi, Aspergillus versicolor, Secondary metabolites, NF-κB inhibitory activitiy

Supporting:

康颖, 张婵娟, 张贺, 刘东. 深海真菌Aspergillus versicolor F77的次级代谢产物[J]. 中国药学(英文版), 2021, 30(1): 42-48.

Ying Kang, Chanjuan Zhang, He Zhang, Dong Liu. Secondary metabolites from a deep-sea-derived Aspergillus versicolor F77[J]. Journal of Chinese Pharmaceutical Sciences, 2021, 30(1): 42-48.

图/表 8

Figure 1. Structures of compounds (1–7) isolated from Aspergillus versicolor F77.

Figure 2. Key HMBC and COSY correlations of 1.

Table 1. The 1H and 13C NMR data of compound 1 (DMSO-d6).

Figure 3. Key HMBC correlations of 2 and 3.

Table 2. The 1H and 13C NMR data of compound 2 (DMSO-d6).

Figure 4. ORTEP view of the X-ray structure of 3.

Table 3. The 1H and 13C NMR data of compound 3 (DMSO-d6).

Figure 5. Inhibition of NF-κB expression of compounds 1, 4–6 (n = 2, 10 mM).

参考文献 21

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深海真菌Aspergillus versicolor F77的次级代谢产物

Secondary metabolites from a deep-sea-derived Aspergillus versicolor F77

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