Synthesis, characterization and biological activities of Schiff bases derived from 2-hydroxy-3-nitrobenzaldehyde

doi:10.5246/jcps.2017.12.096

中国药学(英文版) ›› 2017, Vol. 26 ›› Issue (12): 858-871.DOI: 10.5246/jcps.2017.12.096

Synthesis, characterization and biological activities of Schiff bases derived from 2-hydroxy-3-nitrobenzaldehyde

Monisola Itohan Ikhile^1*, Marthe Carine Djuidje Fotsing¹, Charmaine Arderne², Jane Catherine Ngila¹, Derek Tantoh Ndinteh^1*

1. Department of Applied Chemistry, University of Johannesburg, Doornfontein Campus, P O 17011, Johannesburg 2028, South Africa
2. Department of Chemistry, University of Johannesburg, P O Box 524, Auckland Park, Johannesburg 2006, South Africa

收稿日期:2017-08-19 修回日期:2017-09-25 出版日期:2017-12-27 发布日期:2017-10-11
通讯作者: Tel.: +27115596160, E-mail: miikhile@gmail.com; dndinteh@uj.ac.za
基金资助:
This work was supported by Faculty of science 2017, University of Johannesburg.

Synthesis, characterization and biological activities of Schiff bases derived from 2-hydroxy-3-nitrobenzaldehyde

Monisola Itohan Ikhile^1*, Marthe Carine Djuidje Fotsing¹, Charmaine Arderne², Jane Catherine Ngila¹, Derek Tantoh Ndinteh^1*

1. Department of Applied Chemistry, University of Johannesburg, Doornfontein Campus, PO 17011, Johannesburg 2028, South Africa
2. Department of Chemistry, University of Johannesburg, P O Box 524, Auckland Park, Johannesburg 2006, South Africa

Received:2017-08-19 Revised:2017-09-25 Online:2017-12-27 Published:2017-10-11
Contact: Tel.: +27115596160, E-mail: miikhile@gmail.com; dndinteh@uj.ac.za
Supported by:
This work was supported by Faculty of science 2017, University of Johannesburg.

摘要/Abstract

摘要：

Four novel Schiff bases were synthesized by the condensation reaction of 2-hydroxyl-3-nitrobenzaldehyde with either benzothiazoles or benzimidazolamines. The compounds 1–4 were characterized by spectroscopic and analytical methods. The crystal structures of 6-methoxy-1,3-benzothiazol-2-amine and compound 2 are reported only. The 6-methoxy-1,3-benzothiazol-2-amine was found to crystallize in the orthorhombic crystal system in the space group Pbca, having eight molecules in the unit cell, while compound 2 was found to crystallize in the monoclinic crystal system in the space group P2₁/c.The biological activities of these compounds were investigated by evaluating their antibacterial, antifungal, antimalarial, anti-HIV and anti-trypanosomiasis activities. These compounds displayed very interesting antibacterial, antifungal, antimalarial, anti-trypanosomiasis, anti-HIV and low cytotoxicity activity against HeLa cells.

关键词: Schiff bases, Biological activity, Synthesis, X-ray diffraction Characterization

Abstract:

Key words: Schiff bases, Biological activity, Synthesis, X-ray diffraction Characterization

中图分类号:

R916

Supporting:

Monisola Itohan Ikhile, Marthe Carine Djuidje Fotsing, Charmaine Arderne, Jane Catherine Ngila, Derek Tantoh Ndinteh. Synthesis, characterization and biological activities of Schiff bases derived from 2-hydroxy-3-nitrobenzaldehyde[J]. 中国药学(英文版), 2017, 26(12): 858-871.

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Synthesis, characterization and biological activities of Schiff bases derived from 2-hydroxy-3-nitrobenzaldehyde

Synthesis, characterization and biological activities of Schiff bases derived from 2-hydroxy-3-nitrobenzaldehyde

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