光学比浊法和血栓弹力图法用于判断急性冠脉综合征患者氯吡格雷药物反应性的相关性和一致性对比研究

doi:10.5246/jcps.2016.11.094

中国药学(英文版) ›› 2016, Vol. 25 ›› Issue (11): 838-845.DOI: 10.5246/jcps.2016.11.094

• 【药事管理与临床药学专栏】 • 上一篇下一篇

光学比浊法和血栓弹力图法用于判断急性冠脉综合征患者氯吡格雷药物反应性的相关性和一致性对比研究

聂小燕¹, 胥洋², 扶宇¹, 李俊蕾¹, 梁广楷¹, 张涌³, 陆芸⁴, 刘健^3*, 史录文^1*

1. 北京大学医学部药学院, 北京 100191
2. 北京大学医学部公共卫生学院, 北京 100191
3. 北京大学人民医院心血管内科, 北京 100044
4. Hennepin County Medical Center, 明尼阿波利斯 55415, 明尼苏达州美国

收稿日期:2016-09-15 修回日期:2016-10-29 出版日期:2016-11-26 发布日期:2016-11-06
通讯作者: Tel.: +86-010-82805019, +86-010-88326216, E-mail: niexy@bjmu.edu.cn, drjianliu@163.com, shilu@bjmu.edu.cn
基金资助:
Beijing Higher Education Young Elite Teacher Project (Grant No. YETP0064) from Beijing Municipal Education Commission.

The correlation and consistency of light transmission aggregometry and thrombelastography in identifying high clopidogrel on-treatment platelet reactivity in patients with acute coronary syndrome

Xiaoyan Nie¹, Yang Xu², Yu Fu¹, Junlei Li¹, Guangkai Liang¹, Yong Zhang³, Yun Lu⁴, Jian Liu^3*, Luwen Shi^1*

1. School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
2. School of Public Health, Peking University Health Science Center, Beijing 100191, China
3. Department of Cardiology, Peking university people’s hospital, Beijing 100044, China
4. Department of Pharmacy, Hennepin County Medical Center, Minneapolis, Minnesota 55415, USA

Received:2016-09-15 Revised:2016-10-29 Online:2016-11-26 Published:2016-11-06
Contact: Tel.: +86-010-82805019, +86-010-88326216, E-mail: niexy@bjmu.edu.cn, drjianliu@163.com, shilu@bjmu.edu.cn
Supported by:
Beijing Higher Education Young Elite Teacher Project (Grant No. YETP0064) from Beijing Municipal Education Commission.

摘要/Abstract

摘要：

本文连续纳入176例诊断为急性冠脉综合征且接受常规阿司匹林和氯吡格雷抗血小板治疗的患者, 对比采用光学比浊法和血栓弹力图法检测氯吡格雷用药后血小板抑制率和血小板高反应性的相关性和一致性。结果发现两种方法检测血小板抑制率呈中等相关，检测确定的血小板高反应性呈中等程度一致性，未达到高度一致性要求。

关键词: 光学比浊法, 血栓弹力图, 氯吡格雷, 血小板高反应性, 一致性分析

Abstract:

Various platelet function tests are currently used to identify responsiveness to antiplatelet therapy. 176 ACS patients were enrolled and Linear regression and Kappa consistency analysis showed there was a significant but moderate correlation between platelet inhibition rate and a significant but fair agreement between high clopidogrel on-treatment platelet reactivity tested by light transmission aggregometry and thrombelastography.

Key words: Light transmission aggregometry, Thrombelastography, Clopidogrel, High platelet reactivity, Consistency

中图分类号:

R954

Supporting:

聂小燕, 胥洋, 扶宇, 李俊蕾, 梁广楷, 张涌, 陆芸, 刘健, 史录文. 光学比浊法和血栓弹力图法用于判断急性冠脉综合征患者氯吡格雷药物反应性的相关性和一致性对比研究[J]. 中国药学(英文版), 2016, 25(11): 838-845.

Xiaoyan Nie, Yang Xu, Yu Fu, Junlei Li, Guangkai Liang, Yong Zhang, Yun Lu, Jian Liu, Luwen Shi. The correlation and consistency of light transmission aggregometry and thrombelastography in identifying high clopidogrel on-treatment platelet reactivity in patients with acute coronary syndrome[J]. Journal of Chinese Pharmaceutical Sciences, 2016, 25(11): 838-845.

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光学比浊法和血栓弹力图法用于判断急性冠脉综合征患者氯吡格雷药物反应性的相关性和一致性对比研究

The correlation and consistency of light transmission aggregometry and thrombelastography in identifying high clopidogrel on-treatment platelet reactivity in patients with acute coronary syndrome

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