Prostate cancer and chemoprevention by natural dietary phytochemicals

doi:10.5246/jcps.2016.09.071

中国药学(英文版) ›› 2016, Vol. 25 ›› Issue (9): 633-650.DOI: 10.5246/jcps.2016.09.071

• 【传统中药和植物药的癌症预防专栏】 • 下一篇

Prostate cancer and chemoprevention by natural dietary phytochemicals

Asia Abed Al-Mahmood^1,2, Limin Shu³, Hyuck Kim³, Christina Ramirez^2,4, Douglas Pung², Yue Guo^1,2, Wenji Li³, Ah-Ng Tony Kong^2,3*

1. Graduate Program in Pharmaceutical Sciences, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
2. Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
3. Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
4. Graduate Program in Cellular and Molecular Pharmacology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA

收稿日期:2016-03-23 修回日期:2016-04-10 出版日期:2016-09-28 发布日期:2016-04-30
通讯作者: Tel.: +1-884-445-6369/8, Fax: +1-732-445-3134, E-mail: kongt@pharmacy.rutgers.edu
基金资助:
This work was supported in part by Institutional Funds and from the National Cancer Institute (Grant No. R01-CA118947, R01-CA152826), the National Center for Complementary and Alternative Medicines and the Office of Dietary Supplements (Grant No. R01AT007065).

Prostate cancer and chemoprevention by natural dietary phytochemicals

Asia Abed Al-Mahmood^1,2, Limin Shu³, Hyuck Kim³, Christina Ramirez^2,4, Douglas Pung², Yue Guo^1,2, Wenji Li³, Ah-Ng Tony Kong^2,3*

1. Graduate Program in Pharmaceutical Sciences, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
2. Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
3. Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
4. Graduate Program in Cellular and Molecular Pharmacology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA

Received:2016-03-23 Revised:2016-04-10 Online:2016-09-28 Published:2016-04-30
Contact: Tel.: +1-884-445-6369/8, Fax: +1-732-445-3134, E-mail: kongt@pharmacy.rutgers.edu
Supported by:
This work was supported in part by Institutional Funds and from the National Cancer Institute (Grant No. R01-CA118947, R01-CA152826), the National Center for Complementary and Alternative Medicines and the Office of Dietary Supplements (Grant No. R01AT007065).

摘要/Abstract

摘要：

Prostate cancer is the second leading cancer among men in the United States. Several studies have correlated the development of prostate cancer with diet and life-style. Therefore, a balanced diet and improved life style might inhibit prostate cancer progression. Cancer chemoprevention has emerged as an important factor in controlling cancer development through natural or synthetic compounds. Oxidative stress is among the factors contributing to prostate cancer development. The transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2) controls detoxifying antioxidant enzymes expression by binding to the antioxidant response element (ARE) in the promoter of these genes to activate their expression. Many natural products can fight oxidative stress and protects cells from DNA damage by activating the Nrf2/ARE pathway. High consumption of fruits and vegetables can reduce disease incidence and invasive tumors. In this review, the roles of important fruit and vegetable phytochemicals in regulating prostate cancer progression and tumor growth are discussed.

关键词: Prostate cancer, Phytochemicals, Chemoprevention, Nuclear factor (erythroid-derived 2)-like 2, Oxidative stress, Antioxidant response element

Abstract: Prostate cancer is the second leading cancer among men in the United States. Several studies have correlated the development of prostate cancer with diet and life-style. Therefore, a balanced diet and improved life style might inhibit prostate cancer progression. Cancer chemoprevention has emerged as an important factor in controlling cancer development through natural or synthetic compounds. Oxidative stress is among the factors contributing to prostate cancer development. The transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2) controls detoxifying antioxidant enzymes expression by binding to the antioxidant response element (ARE) in the promoter of these genes to activate their expression. Many natural products can fight oxidative stress and protects cells from DNA damage by activating the Nrf2/ARE pathway. High consumption of fruits and vegetables can reduce disease incidence and invasive tumors. In this review, the roles of important fruit and vegetable phytochemicals in regulating prostate cancer progression and tumor growth are discussed.

Key words: Prostate cancer, Phytochemicals, Chemoprevention, Nuclear factor (erythroid-derived 2)-like 2, Oxidative stress, Antioxidant response element

中图分类号:

R962

Supporting:

Asia Abed Al-Mahmood, Limin Shu, Hyuck Kim, Christina Ramirez, Douglas Pung, Yue Guo, Wenji Li, Ah-Ng Tony Kong. Prostate cancer and chemoprevention by natural dietary phytochemicals[J]. 中国药学(英文版), 2016, 25(9): 633-650.

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Prostate cancer and chemoprevention by natural dietary phytochemicals

Prostate cancer and chemoprevention by natural dietary phytochemicals

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