Determination of the heavy metal content of Entoban herbal medicinal product

doi:10.5246/jcps.2015.11.097

中国药学(英文版) ›› 2015, Vol. 24 ›› Issue (11): 764-769.DOI: 10.5246/jcps.2015.11.097

Determination of the heavy metal content of Entoban herbal medicinal product

Sadia Shakeel², Zeeshan Ahmed Sheikh¹, Khan Usmanghani^1,3, Nadeem Khalid¹, Zafar Ali¹, Somia Gul³, Safila Naveed^3*

1. Herbion Pakistan (Pvt.) Ltd., Karachi, Pakistan 75400
2. Faculty of Pharmacy, Dow University of Health Sciences, Karachi, Pakistan 74200
3. Faculty of Pharmacy Jinnah University for Women Karachi, Pakistan 74600

收稿日期:2015-08-15 修回日期:2015-09-10 出版日期:2015-11-20 发布日期:2015-09-26
通讯作者: Tel.: 00923002621917, E-mail: safila117@yahoo.com

Determination of the heavy metal content of Entoban herbal medicinal product

Sadia Shakeel², Zeeshan Ahmed Sheikh¹, Khan Usmanghani^1,3, Nadeem Khalid¹, Zafar Ali¹, Somia Gul³, Safila Naveed^3*

1. Herbion Pakistan (Pvt.) Ltd., Karachi, Pakistan 75400
2. Faculty of Pharmacy, Dow University of Health Sciences, Karachi, Pakistan 74200
3. Faculty of Pharmacy Jinnah University for Women Karachi, Pakistan 74600

Received:2015-08-15 Revised:2015-09-10 Online:2015-11-20 Published:2015-09-26
Contact: Tel.: 00923002621917, E-mail: safila117@yahoo.com

摘要/Abstract

摘要：

The levels of As, Cd, Pb and Hg were investigated in the medicinal herbal syrup Entoban, which is widely used in the management of non-specific diarrhea and acute intestinal infections of various etiologies. The ingredients in Entoban syrup include 6 potent herbal drugs: Aegle marmelose, Berberis aristata, Butea frondosa, Holarrhena antidysenterica, Myrtus communis, and Quercus infectoria. Entoban medicinal plant syrup was analyzed for As, Cd, Pb and Hg by flame atomic absorption spectroscopy (FAAS). Contents of heavy metals in the examined samples were in the range: As (0.074–10.0 ppm); Cd (0.020–0.3 ppm); Pb (0.00–10.0 ppm) and Hg (0.00–1.0 ppm). Results were compared with permissible limit acceptability intake (AHPA). According to determined amounts of heavy metals, the investigated Entoban syrup samples were validated and considered safe for human consumption.

关键词: Heavy metals, Flame atomic absorption spectroscopy, Medicinal plants, Entoban syrup

Abstract:

Key words: Heavy metals, Flame atomic absorption spectroscopy, Medicinal plants, Entoban syrup

中图分类号:

R284

Supporting:

Sadia Shakeel, Zeeshan Ahmed Sheikh, Khan Usmanghani, Somia Gul, Safila Naveed. Determination of the heavy metal content of Entoban herbal medicinal product[J]. 中国药学(英文版), 2015, 24(11): 764-769.

Sadia Shakeel, Zeeshan Ahmed Sheikh, Khan Usmanghani, Somia Gul, Safila Naveed. Determination of the heavy metal content of Entoban herbal medicinal product[J]. Journal of Chinese Pharmaceutical Sciences, 2015, 24(11): 764-769.

参考文献

[1] Abou-El-Wafa, M.H.; Awadallah, R.M.; Rasheed, M.N.. J. Sci. Ind. Res. 1995, 38, 410-413.

[2] Özbilgin, A.; Cenk, D.; Kilimcioğlu, A.A.; Hüsniye, K.; Özgür, K.; Veciha, Ö.E.; Tuba, T.; İpek, Ö. Kafkas Univ. Vet. Fak. Derg. 2013, 19, 511-516.

[3] American Herbal Products Association. December 2009. Heavy Metals: Analysis and Limits in Herbal Dietary Supplements. AHPA: Silver Spring, MD, USA 28.

[4] Roxb, E.; Banji, D.; Otilia, B. Indian J. Pharm. Sci. 2010, 72, 238-240.

[5] Huheey, J.E.; Keiter, E.A.; Keiter, R.L. Inorganic Chemistry, 4^th ed., Pearson Education Inc., USA, 2000, 889.

[6] Henok, B.; Ariaya, H. Middle-East J. Sci. Res. 2013, 13, 938-943.

[7] Julie Dennis 2012 International Herb & Botanical Trends, published July 1, 2013, http://www.nutraceuticalsworld. com/issues/2012-07/view_features/2012-international-herb-botanical-trends/

[8] Kishan, P.S.; Sanjib, B.; Pradeep, S. J. Agric. Environ. Sci. 2014, 14, 1125-1129.

[9] Pin, K.Y.; Chuah, T.G.; Abdull Rashih, A.; Rasadah, M.A.; Choong, T.S.Y.; Law, C.L. Inter. J. Engineer. 2006, 2, 167-174.

[10] Ebdon, L.; Evans, H.; Fisher, S.; Hill, S.J. An Introduction to Analytical Atomic Spectrometry, John Wiley & Sons, England, 1998, 17-51.

[11] Muhammad, I.; Naveed, M.; Welayath, S. Pakistan Pak. J. Bot. 2013, 45, 141-144.

[12] Martin, E. Front. Pharm. 2013, 4,177-179.

[13] Nassar, M.I.; El-Sayed, A.A.; Ahmed, R.F.; El-Khrisy, E.A.; Ibrahim, K.M.; Sleem, A.A. Pharmacognosy Res. 2010, 2, 325.

[14] Naithani, V.; Pathak, N. Inter. J. Pharm. Sci. Drug Res. 2010, 2, 137-141.

[15] Pallab, M.; Dhananjay H.; Uday, B.; Dipak, K.M. Indian J. Exper. Biology. 2009, 47, 949-861.

[16] Dzomba, P.T.; Chayamiti, E. Bull. Environ. Pharmacol. Life Sci. 2012, 1, 28-33.

[17] Peerarat, T.; Pattana, P.; Kitja, S. Tradit. Med. Nutraceuticals. 2005, 6, 680.

[18] Ziarati, P. J. Environ. Anal. Toxicol. 2012, 2, 120-123.

[19] Robert, B.; Saper, S.N.; Kales, J.P.; Michael, J.B.; David, M.; Eisenberg, R.B.; Davis, R. S.P. JAMA. 2004, 292, 2868-2873.

[20] Gan, R.Y. Int. J. Modern Biol. Med. 2012, 1, 48-81.

[21] Ali shah, S.M.; Khan, U.; Naveed, A.; Asif, H.M. Akram, M.; Ahmed, K. Inter. J. Phytomedicine. 2010, 2, 345-348.

[22] Schwarz, K. Clin. Chem. Chem. Toxicol. Metals. 1977, 135.

[23]Brijesh, S.; Poonam, D.; Pundarikakshudu, T.; Noshir, A.; Tannaz, B. Compl. Altern. Med. 2009, 47, 1-12.

[24] WHO Traditional Medicine Strategy. 2014-2023, ISBN 978 924 150609, Geneva, Switzerland, 2013, 70.

Determination of the heavy metal content of Entoban herbal medicinal product

Determination of the heavy metal content of Entoban herbal medicinal product

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 1

编辑推荐

Metrics

本文评价