Quality assessment and dissolution profile comparison studies on 250-mg mefenamic acid tablets available in local market of Karachi

doi:10.5246/jcps.2015.10.086

中国药学(英文版) ›› 2015, Vol. 24 ›› Issue (10): 673-677.DOI: 10.5246/jcps.2015.10.086

Quality assessment and dissolution profile comparison studies on 250-mg mefenamic acid tablets available in local market of Karachi

Farya Zafar¹, Huma Ali¹, Shabana Naz Shah², Safila Naveed^3*, Shehla Siddiqui¹

1. Faculty of Pharmacy, Ziauddin University, Karachi 74700, Pakistan
2. Martin Dow Pharmaceutical Pakistan Limited, Martin, Karachi 75632, Pakistan
3. Jinnah University for Woman Karachi, Karachi 74600, Pakistan

收稿日期:2015-05-25 修回日期:2015-06-30 出版日期:2015-10-21 发布日期:2015-07-15
通讯作者: Tel.: 03002621917, E-mail: safila117@yahoo.com

Quality assessment and dissolution profile comparison studies on 250-mg mefenamic acid tablets available in local market of Karachi

Farya Zafar¹, Huma Ali¹, Shabana Naz Shah², Safila Naveed^3*, Shehla Siddiqui¹

1. Faculty of Pharmacy, Ziauddin University, Karachi 74700, Pakistan
2. Martin Dow Pharmaceutical Pakistan Limited, Martin, Karachi 75632, Pakistan
3. Jinnah University for Woman Karachi, Karachi 74600, Pakistan

Received:2015-05-25 Revised:2015-06-30 Online:2015-10-21 Published:2015-07-15
Contact: Tel.: 03002621917, E-mail: safila117@yahoo.com

摘要/Abstract

摘要：

In the present study, we aimed todetermine the quality of different brands (Test₁–Test₆) of mefenamic acid, which are commercially available in local market of Karachi, Pakistan. Various quality evaluation tests, including weight variation, hardness, thickness, friability, disintegration, assay and drug release, were carried out. Results were found to be in acceptable limits. Moreover, release profiles were compared using different dissolution media, such as phosphate buffer pH 6.8, 7.4 and biorelevant media (FaSSGF, FaSSIF, FeSSIF and SCoF). Release profiles at pH 6.8 and 7.4 were evaluated by one-way ANOVA, model-independent and model-dependent methods. Results of ANOVA showed that no significant difference was found among tester and reference brands (Test₁–Test₆). Similarly, all the brands were found to be best fitted with Weibull model.

关键词: Mefenamic acid, One-way ANOVA, Model-independent, Model-dependent method, Biorelevant media

Abstract:

Key words: Mefenamic acid, One-way ANOVA, Model-independent, Model-dependent method, Biorelevant media

中图分类号:

R944.4

Supporting:

Farya Zafar, Huma Ali, Shabana Naz Shah, Safila Naveed, Shehla Siddiqui. Quality assessment and dissolution profile comparison studies on 250-mg mefenamic acid tablets available in local market of Karachi[J]. 中国药学(英文版), 2015, 24(10): 673-677.

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Quality assessment and dissolution profile comparison studies on 250-mg mefenamic acid tablets available in local market of Karachi

Quality assessment and dissolution profile comparison studies on 250-mg mefenamic acid tablets available in local market of Karachi

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