http://jcps.bjmu.edu.cn

中国药学(英文版) ›› 2014, Vol. 23 ›› Issue (5): 306-310.DOI: 10.5246/jcps.2014.05.042

• 【研究论文】 • 上一篇    下一篇

胆木中一个新吲哚生物碱的分离与结构鉴定

皮晓雪1, 谢可辉1, 涂光忠2, 蔡田芝1, 杨蓉1, 吴琼1, 付宏征1*   

  1. 1. 北京大学医学部 天然药物与仿生药物国家重点实验室, 北京 100191
    2. 北京微量化学研究所, 北京 100191 
  • 收稿日期:2013-05-02 修回日期:2013-05-21 出版日期:2014-05-23 发布日期:2013-06-26
  • 通讯作者: Tel./Fax: 86-10-82805212; E-mail: drhzfu@sina.com
  • 基金资助:
    National Natural Science Foundation of China (Grant No. 30973628).

A new indole alkaloid from Nauclea officinalis (Pierre ex Pitard) Merr. et Chun

Xiaoxue Pi1, Kehui Xie1, Guangzhong Tu2, Tianzhi Cai1, Rong Yang1, Qiong Wu1, Hongzheng Fu1*   

  1. 1. State Key Laboratory of Natural Biomimetic Drugs, School of Pharmaceutical Science, Peking University Health Science Center, Beijing 100191, China
    2. Beijing Institute of Microchemistry, Beijing 100191, China
  • Received:2013-05-02 Revised:2013-05-21 Online:2014-05-23 Published:2013-06-26
  • Contact: Tel./Fax: 86-10-82805212; E-mail: drhzfu@sina.com
  • Supported by:
    National Natural Science Foundation of China (Grant No. 30973628).

摘要:

胆木中分离得到一个新的吲哚生物碱 paratunamide E (1) 以及6个已知吲哚生物碱, paratunamide A (2), nauclealotide C(3), nauclealotide A (4), vincosamide (5), strictosamide (6), naucleamide F (7)。其中, 化合物7是首次从该植物中分离得到, 通过波谱学的方法确定了化合物的平面结构和相对构型。

关键词: 胆木, 吲哚生物碱, 结构解析

Abstract:

From the aerial parts of Nauclea officinalis (Pierre ex Pitard) Merr. et Chun, one new indole alkaloid paratunamide E (1)has been isolated together with six known indole alkaloids, paratunamide A (2), nauclealotide C (3), nauclealotide A (4), vincosamide (5), strictosamide (6) and naucleamide F (7). Naucleamide F (7) was isolated from Nauclea officinalis for the first time. All of the seven compounds above were elucidated by spectroscopic methods including 1 D and 2 D NMR spectroscopic analyses.

Key words: Nauclea officinalis , Indole alkaloid, Structural identification

中图分类号: 

Supporting: National Natural Science Foundation of China (Grant No. 30973628).