中药醒鼻温敏凝胶的鼻粘膜毒性考察

doi:10.5246/jcps.2012.01.010

中药醒鼻温敏凝胶的鼻粘膜毒性考察

褚克丹^*, 郑健, 李煌, 徐伟, 谢伟容, 夏裕发

1. 福建中医药大学药学院, 福建福州 350108
2. 福建中医药大学附属人民医院, 福建福州 350004

收稿日期:2011-11-14 修回日期:2011-12-14 出版日期:2012-01-01 发布日期:2012-01-01
通讯作者: 褚克丹*

Studies on ciliotoxicity of nasal thermosensible gels of Chinese medicine
Xingbi

Ke-Dan Chu^*, Jian Zheng, Huang Li, Wei Xu, Wei-Rong Xie, Yu-Fa Xia

1. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China
2. The People's Hospital of Fujian Province, Fuzhou 350004, China

Received:2011-11-14 Revised:2011-12-14 Online:2012-01-01 Published:2012-01-01
Contact: Ke-Dan Chu*

摘要/Abstract

摘要： 本研究采用生理盐水作为空白对照, 含1%盐酸麻黄碱的呋麻滴鼻剂作为阴性对照, 显微镜下观察中药醒鼻温敏凝胶对蟾蜍上颚粘膜纤毛运动的影响以及鼻腔给药后, 大鼠鼻粘膜组织病理切片变化情况, 探讨中药醒鼻温敏凝胶对鼻粘膜纤毛的毒性。结果表明中药醒鼻温敏凝胶对鼻黏膜纤毛运动无影响, 与生理盐水的相对运动百分率为94.1%; 鼻粘膜组织切片显示无显著病理变化情况。综合我们的实验结果, 可以得出中药醒鼻温敏凝胶安全性较高, 无明显纤毛毒性, 可用于鼻腔给药。

关键词: 中药醒鼻温敏凝胶, 纤毛毒性, 鼻腔给药, 蟾蜍上颚粘膜

Abstract: Bufo gargarizans maxillary mucosal cilia movement and the ciliotoxicity in rats nasal mucosa. The saline water was used as a blank control, and 1% hydrochloric acid of methamphetamine Massachusetts was used as the negative control. Compared with normal saline control, the relative percentage of the lasting time of ciliary movement treated with Chinese medicine Xingbi was 94.1%. There was no remarkable pathological change in the tissue slice of nasal mucosa, and no stimulation on nasal mucous membrane was observed. So these data suggest that nasal thermosensible gel of Chinese medicine Xingbi is of high safety. It has no damage to the mucosa of toads and rats and can be used for intranasal administration.

Key words: Nasal thermosensible gels of Chinese medicine Xingbi, Ciliotoxicity, Intranasal administration, Toad palate

中图分类号:

R285

Supporting:

Foundation items: National Natural Science Foundation of China (Grant No. 81073117) and the construction of college service routines in fujian province key project (Grant No. 2008FG-06).
^*Corresponding author. Tel.: 86-591-22861661

褚克丹^*, 郑健, 李煌, 徐伟, 谢伟容, 夏裕发. 中药醒鼻温敏凝胶的鼻粘膜毒性考察[J]. , DOI: 10.5246/jcps.2012.01.010.

Ke-Dan Chu^*, Jian Zheng, Huang Li, Wei Xu, Wei-Rong Xie, Yu-Fa Xia. Studies on ciliotoxicity of nasal thermosensible gels of Chinese medicine
Xingbi[J]. , DOI: 10.5246/jcps.2012.01.010.