关键词: 蛋白酶体抑制剂, 蛋白酶体抑制剂, 蛋白酶体抑制剂, 保护的氨烷基亚磺酰双内酯, 保护的氨烷基亚磺酰双内酯, 保护的氨烷基亚磺酰双内酯, 合成, 合成, 合成

Abstract: Aim To synthesize protected aminoalkyl sulfinyl dilactones which were useful as the synthetic intermediates or the Cterminal pharmacophores of potential peptidomimetic proteasome inhibitors. Methods Organic reactions such as reduction, oxidation, olefination, and dihydroxylation were used. Results A convenient synthetic procedure to afford a series of aminoalkyl sulfinyl dilactones was presented, which would be useful in the synthesis of five- or six-member sulfinyl dilactones. Conclusion Four aminoalkyl sulfinyl dilactones connecting different α-amino acids were synthesized.

Key words: Proteasome inhibitors, Proteasome inhibitors, Protected aminoalkyl sulfinyl dilactone, Protected aminoalkyl sulfinyl dilactone, Synthesis, Synthesis