汪贻广/陈斌龙团队发展精准调控II型免疫原性细胞死亡的内质网应激靶向递送策略

中国药学(英文版) ›› 2025, Vol. 34 ›› Issue (7): 695-696.

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汪贻广/陈斌龙团队发展精准调控II型免疫原性细胞死亡的内质网应激靶向递送策略

北京大学药学院天然药物及仿生药物全国重点实验室

北京大学药学院天然药物及仿生药物全国重点实验室

收稿日期:2025-06-15 修回日期:2025-06-15 接受日期:2025-06-15 出版日期:2025-07-31 发布日期:2025-08-01

The research team of Prof. Yiguang Wang and Prof. Binlong Chen have developed a targeted delivery strategy for endoplasmic reticulum stress to precisely regulate type-II immunogenic cell death

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center

Received:2025-06-15 Revised:2025-06-15 Accepted:2025-06-15 Online:2025-07-31 Published:2025-08-01

摘要/Abstract

摘要： 2025年5月28日, 北京大学药学院天然药物及仿生药物全国重点实验室汪贻广教授、陈斌龙副研究员团队与沈阳药科大学王思玲教授团队合作, 在Advanced Materials期刊发表了题为“An Endoplasmic Reticulum Stress-Specific Nanoinducer Selectively Evokes Type-II Immunogenic Cell Death for Pyroptotic Cancer Immunotherapy”的研究论文。该研究报道了一种pH/组织蛋白酶B双响应纳米载体递送平台 (PCANER), 通过精准诱导内质网 (ER) 应激, 调控II型免疫原性细胞死亡, 为肿瘤免疫治疗提供了创新性策略。

Supporting:

北京大学药学院天然药物及仿生药物全国重点实验室. 汪贻广/陈斌龙团队发展精准调控II型免疫原性细胞死亡的内质网应激靶向递送策略[J]. 中国药学(英文版), 2025, 34(7): 695-696.

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center. The research team of Prof. Yiguang Wang and Prof. Binlong Chen have developed a targeted delivery strategy for endoplasmic reticulum stress to precisely regulate type-II immunogenic cell death[J]. Journal of Chinese Pharmaceutical Sciences, 2025, 34(7): 695-696.

汪贻广/陈斌龙团队发展精准调控II型免疫原性细胞死亡的内质网应激靶向递送策略

The research team of Prof. Yiguang Wang and Prof. Binlong Chen have developed a targeted delivery strategy for endoplasmic reticulum stress to precisely regulate type-II immunogenic cell death

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