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中国药学(英文版) ›› 2025, Vol. 34 ›› Issue (10): 976-976.

• 【新闻】 • 上一篇    

李中军/李忠堂团队在乙酰肝素酶抑制剂的开发及抗肿瘤转移活性研究方面取得进展

北京大学药学院   

  1. 北京大学药学院
  • 收稿日期:2025-09-20 修回日期:2025-09-20 接受日期:2025-09-20 出版日期:2025-11-03 发布日期:2025-11-03

The research team of Prof. Zhongjun Li and Prof. Zhongtang Li has made progress in the development of heparanase inhibitors and the study of their anti-tumor metastasis activity

School of Pharmaceutical Sciences, Peking University Health Science Center   

  1. School of Pharmaceutical Sciences, Peking University Health Science Center
  • Received:2025-09-20 Revised:2025-09-20 Accepted:2025-09-20 Online:2025-11-03 Published:2025-11-03

摘要:

2025年8月22日, 北京大学药学院李中军教授/李忠堂副研究员团队与石河子大学药学院王恒教授团队合作, 在Carbohydrate Polymers期刊发表了题为“Low-molecular-weight dextran sulfate sodium as novel heparanase inhibitor preventing breast cancer metastasis in mice by inhibiting migration and angiogenesis”的研究论文。该研究发现, 低分子量硫酸化葡聚糖通过抑制乙酰肝素酶的活性, 阻断乳腺癌细胞的侵袭和迁移, 为攻克侵袭性乳腺恶性肿瘤提供了新的可靠治疗策略。

Abstract:

The research team of Prof. Zhongjun Li and Prof. Zhongtang Li has made progress in the development of heparanase inhibitors and the study of their anti-tumor metastasis activity.

Supporting: