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中国药学(英文版) ›› 2024, Vol. 33 ›› Issue (4): 366-368.

• 【新闻】 • 上一篇    

王坚成团队在纳米药物促进干细胞软骨再生治疗骨关节炎研究领域取得新进展

北京大学药学院 天然药物及仿生药物全国重点实验室   

  1. 北京大学药学院 天然药物及仿生药物全国重点实验室
  • 收稿日期:2024-04-01 修回日期:2024-04-01 接受日期:2024-04-01 出版日期:2024-04-30 发布日期:2024-04-30

The research group of Prof. Jiancheng Wang has made new progress in the field of nanomedicine promoting cartilage regeneration in osteoarthritis by synergistically enhancing chondrogenesis of mesenchymal stem cells

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center   

  1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center
  • Received:2024-04-01 Revised:2024-04-01 Accepted:2024-04-01 Online:2024-04-30 Published:2024-04-30

摘要:

2024年3月7日, 北京大学药学院天然药物及仿生药物全国重点实验室王坚成教授/朱元军博士团队和北京大学第三医院运动医学江东主任医师团队共同在国际学术期刊ACS Nano在线发表了题为“Nanomedicines Promote Cartilage Regeneration in Osteoarthritis by Synergistically Enhancing Chondrogenesis of Mesenchymal Stem Cells and Regulating Inflammatory Environment”的研究论文。该研究提出了碳酸酐酶IX siRNA(siCA9)调控炎症微环境调控促进Kartogenin(KGN)诱导的间充质干细胞(MSCs)软骨定向分化作用的新策略, 显著提高了MSCs在骨关节炎(OA)治疗中的软骨再生能力, 改善了晚期OA治疗效应。

Abstract:

The research group of Prof. Jiancheng Wang has made new progress in the field of nanomedicine promoting cartilage regeneration in osteoarthritis by synergistically enhancing chondrogenesis of mesenchymal stem cells.

Supporting: