一种有效的芳基乙酮α-溴代的实用方法

一种有效的芳基乙酮α-溴代的实用方法

邢瑞娟, 潘莉, 温西, 王健, 程卯生^*

沈阳药科大学制药工程学院基于靶点的药物设计与研究教育部重点实验室, 辽宁沈阳 110016

收稿日期:2009-12-23 修回日期:2010-07-30 出版日期:2010-09-20 发布日期:2010-09-20
通讯作者: 程卯生*

A practical and efficient procedure for the α-bromination of arylethanones

Rui-Juan Xing, Li Pan, Xi Wen, Jian Wang, Mao-Sheng Cheng^*

Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China

Received:2009-12-23 Revised:2010-07-30 Online:2010-09-20 Published:2010-09-20
Contact: Mao-Sheng Cheng*

摘要/Abstract

摘要： 本文报道了采用溴素进行羰基α-溴代反应而后经亚磷酸二乙酯和三乙胺脱溴反应制得羰基α-单溴代物的方法, 该方法具有实用、收率高和易于工业化等优点。

关键词: α-溴代芳基乙酮, 溴, 亚磷酸二乙酯, α-溴代

Abstract:

A series of α-bromoarylethanones were prepared in high yields by a practical and efficient method. The arylethanones were reacted with bromine to give a mixture of α- and α, α-dibromides, which were debrominated with diethylphosphite in the presence of triethylamine to give the desired α-monobromo products.

Key words: α-Bromoarylethanones, Bromine, Diethylphosphite, α-Bromination

中图分类号:

R916.41

Supporting: ^*Corresponding author. Tel.: 86-24-23986413; fax: 86-24-23995043

邢瑞娟, 潘莉, 温西, 王健, 程卯生^*. 一种有效的芳基乙酮α-溴代的实用方法[J]. .

Rui-Juan Xing, Li Pan, Xi Wen, Jian Wang, Mao-Sheng Cheng^* . A practical and efficient procedure for the α-bromination of arylethanones [J]. .

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