Microwave synthesis and pharmacological activity of Mannich base cyclohexanone derivatives

• 简报 • 上一篇

Microwave synthesis and pharmacological activity of Mannich base cyclohexanone derivatives

Ch. Rajveer^*, B. Stephenrathinaraj, Naveen Kumar Bimal, S. Sudharshini, Ch. Swarnalatha, Prasanta Kumar Choudhury

1. Department of Pharmaceutical Chemistry, Vaagdevi College of Pharmacy, Warangal, Andhrapradesh, India
2. Department of Pharmaceutical Chemistry, K.R.E's Karnataka College of Pharmacy, Bidar, Karnataka, India
3. Department of Pharmaceutics, Royal College of Pharmacy and Health Sciences, Berhampur, Orissa, India

收稿日期:2010-03-09 修回日期:2010-06-10 出版日期:2010-07-15 发布日期:2010-07-15
通讯作者: Ch. Rajveer*

Microwave synthesis and pharmacological activity of Mannich base cyclohexanone derivatives

Ch. Rajveer^*, B. Stephenrathinaraj, Naveen Kumar Bimal, S. Sudharshini, Ch. Swarnalatha, Prasanta Kumar Choudhury

1. Department of Pharmaceutical Chemistry, Vaagdevi College of Pharmacy, Warangal, Andhrapradesh, India
2. Department of Pharmaceutical Chemistry, K.R.E's Karnataka College of Pharmacy, Bidar, Karnataka, India
3. Department of Pharmaceutics, Royal College of Pharmacy and Health Sciences, Berhampur, Orissa, India

Received:2010-03-09 Revised:2010-06-10 Online:2010-07-15 Published:2010-07-15
Contact: Ch. Rajveer*

摘要/Abstract

摘要： We have synthesized mannich base cyclohexanone using microwave irradiation method, and studied their pharmacological activity. Based on analytical and spectral (IR, NMR and Mass) data, a number of mono as well as double mannich base cyclohexanones have been synthesized from primary and secondary amines and formaldehyde, and then purified and characterized. The required 3-aryl-2,4-diacetyl-5-hydroxy-5-methylcyclohexanone was prepared from appropriate aldehyde and acetylacetone. The synthesized compounds were screened for analgesic activity via standard approaches, and they have shown positive analgesic activity.

关键词: Mannich base, Cyclohexanone, Analgesic activity

Abstract: We have synthesized mannich base cyclohexanone using microwave irradiation method, and studied their pharmacological activity. Based on analytical and spectral (IR, NMR and Mass) data, a number of mono as well as double mannich base cyclohexanones have been synthesized from primary and secondary amines and formaldehyde, and then purified and characterized. The required 3-aryl-2,4-diacetyl-5-hydroxy-5-methylcyclohexanone was prepared from appropriate aldehyde and acetylacetone. The synthesized compounds were screened for analgesic activity via standard approaches, and they have shown positive analgesic activity.

Key words: Mannich base, Cyclohexanone, Analgesic activity

中图分类号:

R916.42

Supporting: ^*Corresponding author. Mr. Chiliveri Rajveer, M. Pharm, (Ph.D), Assistant Professor, Department of pharmaceutical Chemistry, Vaagdevi college of Pharmacy, Warangal, Andhrapradesh, India. Tel.: +91-9989567617;

Ch. Rajveer^*, B. Stephenrathinaraj, Naveen Kumar Bimal, S. Sudharshini, Ch. Swarnalatha, Prasanta Kumar Choudhury. Microwave synthesis and pharmacological activity of Mannich base cyclohexanone derivatives [J]. .

[1]	张国宁, 方唯硕^*. 一种合成卡巴他赛的新方法[J]. , 2012, 21(5): 472-476.
[2]	孙晟, 马庆, 孟祥豹, 李庆, 李树春, 黄河清, 李中军^*. 离子液体在甘露糖苷化过程中的β导向性: 一种具有选择性构建1,2-顺式-β-D-甘露糖连接潜力的新方法[J]. , 2011, 20(6): 549-556.
[3]	宁显玲, 马小艳^, 陈柱陀, 朱仁宗, 李超, 王孝伟, 张志丽, 刘俊义^. 咖啡酸苯乙酯及其苯甲酰基衍生物: 合成和单晶X衍射分析[J]. , 2011, 20(1): 37-41.
[4]	朱新荣, 郑毅, 王鹏, 杨士豹, 陈荣, 朱永强^* . 依达拉奉代谢产物的合成 [J]. , 2010, 19(4): 307-311.
[5]	邓喜玲, 张志丽, 王孝伟, 刘俊义^* . 4-[N-甲基-N-(2,3-环氮丙基)]氨基苯甲酸乙酯和N-{4-[N-甲基-N-(2,3-环氮丙基)]氨基}苯甲酰基-L-谷氨酸二乙酯的合成 [J]. , 2010, 19(2): 141-145.

Microwave synthesis and pharmacological activity of Mannich base cyclohexanone derivatives

Microwave synthesis and pharmacological activity of Mannich base cyclohexanone derivatives

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 5

编辑推荐

Metrics

本文评价