关键词: 叠氮碘糖基化, 叠氮碘糖基化, 叠氮碘糖基化, 乳糖烯, 乳糖烯, 乳糖烯, 2-碘代叠氮糖, 2-碘代叠氮糖, 2-碘代叠氮糖, 氨基乳糖苷, 氨基乳糖苷, 氨基乳糖苷

Abstract:

A core trisaccharide of laminin, β-D-Gal-(1→4)-β-D-GlcpNAc-(1→6)-α-D-Manp-OMe, with potential anti-tumor metastatic activity was designed and prepared. 2-Iodoglactosyl azide was used as the donor to construct 2-N-acetamido-2-deoxylactosyl moiety through an azidoiodo-glycosylation reaction. Simultaneously, 1, 2-trans-β-glycosic bond was formed stereoselectively in one step with a moderate yield. This novel procedure avoided the use of 2-amino-2-deoxyglucose as both donor and acceptor.

Key words: Azidoiodo-glycosylation, Azidoiodo-glycosylation, Lactal, Lactal, 2-Iodoglycosyl azide, 2-Iodoglycosyl azide, Lactosamine, Lactosamine, ,