基于KRN7000的结构改造以及它们对自然杀伤T细胞活化作用的构效关系

摘要/Abstract

摘要： 能够被自然杀伤T细胞所识别的α-半乳糖基神经酰胺具有潜在的治疗肿瘤、感染性疾病和自身免疫性疾病的用途, 已引起了研究者们越来越多的注意。人们在寻找具有更好活性的化合物方面取得了不少进展, 在理解这些自然杀伤T细胞配体的构效关系方面进行了许多探索。KRN7000是用于自然杀伤T细胞刺激研究的一种主要的糖脂类化合物。本文对近年来基于KRN7000的各种结构改造以及在这些结构改造基础上所获得的构效关系进行详细的综述.

关键词: α-半乳糖基神经酰胺, α-半乳糖基神经酰胺, α-半乳糖基神经酰胺, 自然杀伤T细胞活化, 自然杀伤T细胞活化, 自然杀伤T细胞活化, 糖脂, 糖脂, 糖脂, 免疫调节剂, 免疫调节剂, 免疫调节剂, 构效关系, 构效关系, 构效关系, , ,

Abstract:

α-Galactosylceramides, which can be recognized by natural killer T (NKT) cells, are now attracting more and more attetion due to their therapeutic potential in cancer, infection and autoimmune diseases. Advances have been achieved in discovering compounds with better activities and efforts have been made to understand the structure-activity relationships (SARs) of these NKT cell ligands. In this review, we discuss the structure modifications based on KRN7000, the principal glycolipid used in the study of NKT cell stimulation, and the SARs based on these modified structures.

Key words: α-Galactosylceramide, α-Galactosylceramide, NKT cell activation, NKT cell activation, Glycolipid, Glycolipid, Immunoregulatory agent, Immunoregulatory agent, Structure-activity relationship, Structure-activity relationship, ,

Supporting: Foundation items: National Natural Science Foundation of China (Grant No. 90713010), “863” Program from the Ministry of Science and Technology of China (Grant No. 2006AA09Z405).
^*Corresponding author. Tel.: 86-10-62014949; fax: 86-10-82802724

张蕾, 叶新山*. 基于KRN7000的结构改造以及它们对自然杀伤T细胞活化作用的构效关系[J]. .

Lei Zhang, Xin-Shan Ye*. Structure modifications based on KRN7000 and their SARs in activating NKT cells[J]. .

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