软珊瑚Sarcophyton sp.中一个新西松烷型二萜的结构解析

软珊瑚Sarcophyton sp.中一个新西松烷型二萜的结构解析

别玮, 邓志威, 徐岷涓, 林文翰^*

1. 北京大学天然药物及仿生药物国家重点实验室, 北京 100191;
2. 北京师范大学分析测试中心, 北京 100072

收稿日期:2008-03-10 修回日期:2008-08-10 出版日期:2008-09-15 发布日期:2008-09-15
通讯作者: 林文翰*

Structural elucidation of a new cembranoid diterpene from the Chinese soft coral Sarcophyton sp.

Wei Bie, Zhi-Wei Deng, Min-Juan Xu, Wen-Han Lin^*

1. The State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China;
2. Analytical and Testing Center, Beijing Normal University, Beijing 100875, China

Received:2008-03-10 Revised:2008-08-10 Online:2008-09-15 Published:2008-09-15
Contact: Wen-Han Lin*

摘要/Abstract

摘要： 对南海软珊瑚Sarcophyton sp.中的西松烷二萜类成份进行研究, 从发现具有新颖结构的次生代谢产物。采用多种色谱手段进行分离纯化, 通过理化性质和光谱分析确定化合物结构。分离得到1个新的西松烷二萜类化合物, 命名为Sarcophyolide A (1), 和一个已知西松烷二萜类化合物7α, 8β-dihydroxydeepoxysarcophine (2)。利用现代波谱确定新化合物的结构。

关键词: Sarcophyton sp., Sarcophyton sp., Sarcophyton sp., 西松烷二萜, 西松烷二萜, 西松烷二萜, Sarcophyolide A, Sarcophyolide A, Sarcophyolide A, 结构解析, 结构解析, 结构解析

Abstract:

To investigate the cembranoid diterpenes from the soft coral Sarcophyton sp. collected in the South China Sea. Repeatedly column chromatography was performed for the isolation and purification. The structures were elucidated on the basis of extensive spectral data (IR, MS, 1D- and 2D-NMR) analysis by comparing with literature data. A new cembranoid diterpene namely sarcophyolide A (1), together with 7α, 8β-dihydroxydeepoxysarcophine (2) were isolated from this species. The cembranoid diterpenes with γ-lactone could be chemotaxonomic markers of Sarcophyton sp.

Key words: Sarcophyton sp., Sarcophyton sp., Cembranoid diterpene, Cembranoid diterpene, Sarcophyolide A, Sarcophyolide A, Structural elucidation, Structural elucidation

Supporting: Foundation items: National Natural Science Foundation of China (Grant No. 30672607), the National Hi-Tech Projects (Grant No. 2006AA09Z446, 2006DFA31100 and 2006AA09Z405), China Uni-PhD Base Project (Grant No. 20060001149), and International Cooperation Projects of BMBF-MOST.
^*Corresponding author. Tel.: 86-10-82806188; fax: 86-10-82802724;

别玮, 邓志威, 徐岷涓, 林文翰^*. 软珊瑚Sarcophyton sp.中一个新西松烷型二萜的结构解析
[J]. .

Wei Bie, Zhi-Wei Deng, Min-Juan Xu, Wen-Han Lin^*. Structural elucidation of a new cembranoid diterpene from the Chinese soft coral Sarcophyton sp.
[J]. .

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