大鼠灌胃给予不同双黄连剂型后黄芩苷的群体药物动力学研究

大鼠灌胃给予不同双黄连剂型后黄芩苷的群体药物动力学研究

张关敏, 陈文倩, 李良, 胡渝慧, 张彦青, 易红, 杨华, 卢炜^*

1.北京大学药学院药剂学系, 北京 100083;
2.北京大学天然药物及仿生药物国家重点实验室, 北京 100083;
3.中国中医科学院中药研究所, 北京 100700

收稿日期:2007-06-18 修回日期:2008-01-10 出版日期:2008-03-15 发布日期:2008-03-15
通讯作者: 卢炜*

Population pharmacokinetic analysis of baicalin after oral administration of different Shuang-Huang-Lian formulations to rats

Guan-Min Zhang, Wen-Qian Chen, Liang Li, Yu-Hui Hu, Yan-Qing Zhang, Hong Yi, Hua Yang, Wei Lu^*

1. Department of Pharmaceutics, School of Pharmaceutical Science, Peking University, Beijing 100083, China;
2. The State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 10083, China;
3. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China

Received:2007-06-18 Revised:2008-01-10 Online:2008-03-15 Published:2008-03-15
Contact: Wei Lu*

摘要/Abstract

摘要：

关键词: 黄芩苷, 黄芩苷, 黄芩苷, 群体药物动力学, 群体药物动力学, 群体药物动力学, 肠肝循环, 肠肝循环, 肠肝循环, 双黄连, 双黄连, 双黄连

Abstract:

Key words: Baicalin, Baicalin, Population pharmacokinetics, Population pharmacokinetics, Enterohepatic recirculation, Enterohepatic recirculation, Shuang-Huang-Lian, Shuang-Huang-Lian

中图分类号:

R943

R969.1

Supporting:

Foundating item: National Natural Science Foundation of China (Grant No. 30472195).
^*Corresponding author. Tel./fax: 86-10-82801717

张关敏, 陈文倩, 李良, 胡渝慧, 张彦青, 易红, 杨华, 卢炜^*. 大鼠灌胃给予不同双黄连剂型后黄芩苷的群体药物动力学研究[J]. .

Guan-Min Zhang, Wen-Qian Chen, Liang Li, Yu-Hui Hu, Yan-Qing Zhang, Hong Yi, Hua Yang, Wei Lu^*. Population pharmacokinetic analysis of baicalin after oral administration of different Shuang-Huang-Lian formulations to rats[J]. .

参考文献

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