http://jcps.bjmu.edu.cn

• 研究论文 • 上一篇    下一篇

具有二肽结构的ADPR类似物的合成

张超, 杨振军, 张亮仁*, 张礼和   

  1. 北京大学药学院 天然药物及仿生药物国家重点实验室, 北京 100083
  • 收稿日期:2007-06-17 修回日期:2007-11-10 出版日期:2007-12-15 发布日期:2007-12-15
  • 通讯作者: 张亮仁*

Synthesis of novel ADPR analogues: substitution of pyrophosphate linkage by dipeptide

Chao Zhang, Zhen-Jun Yang, Liang-Ren Zhang*, Li-He Zhang   

  1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
  • Received:2007-06-17 Revised:2007-11-10 Online:2007-12-15 Published:2007-12-15
  • Contact: Liang-Ren Zhang*

摘要: 为进一步探讨ADPR的生物学功能,本文设计并合成了用天门冬氨酸二肽代替焦磷酸结构的一类新型ADPR类似物。通过以5'-氨基腺苷或其模拟物为起始原料, 采用类似于液相肽的合成方法,成功地构建了四个目标分子, 其结构经1H NMRHRMS等进行了鉴定。本研究为新型ADPR类似物的合成提供了一条便利途径。

关键词: ADPR, ADPR, ADPR, 核苷, 核苷, 核苷, 类似物, 类似物, 类似物, 合成, 合成, 合成

Abstract:

For investigating the biological function of ADPR, four novel analogues (compounds 25) in which the pyrophosphate linkage was replaced by the aspartic acid dipeptide were synthesized. 5'-Amino adenosine or its analogues was used as the starting material, liquid phase peptide synthesis strategy was used to construct these ADPR analogues. The structures were characterized by 1H NMR and HRMS spectra. This study provides a versatile synthesis of peptide modified ADPR analogues and helps to understand the structure-activity relationship of ADPR.

Key words: ADPR, ADPR, Nucleoside, Nucleoside, Analogues, Analogues, Synthesis, Synthesis

中图分类号: 

Supporting: Foundation item: National Natural Science Foundation of China (Grant No. 20472007) and the Research Found for the Docroral Program of Higher Education.
*Corresponding author. Tel.: 86-10-82802567