北极蒿与中药常用蒿属植物的化学成分比较

北极蒿与中药常用蒿属植物的化学成分比较

田芳, 刘丽, 窦德强^*, 康廷国, Smith David

1.辽宁中医药大学药学院, 辽宁大连 116000;
2.Alaska Green Gold, Anchorage, AK 99510, USA

收稿日期:2006-10-21 修回日期:2007-02-10 出版日期:2007-03-15 发布日期:2007-03-15
通讯作者: 窦德强*

Chemical comparison of Artemisia borealis and three Chinese Artemisia plants

Fang Tian, Li Liu, De-Qiang Dou^*, Ting-Guo Kang, Smith David

1. College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116620, China;
2. Alaska Green Gold, Anchorage, AK 99510, USA

Received:2006-10-21 Revised:2007-02-10 Online:2007-03-15 Published:2007-03-15
Contact: De-Qiang Dou*

摘要/Abstract

摘要： 目的比较北极蒿与三种中药常用蒿属植物的化学成分并对北极蒿的化学成分进行初步研究。方法采用薄层色谱及GC-MS比较小极性成分及挥发油的区别; 采用HPLC指纹图谱对极性较大成分进行比较。结论从北极蒿挥发油中分离出52个色谱峰, 共鉴定了48个成分, 占挥发油总成分的92%以上, 其主要成分为香木兰烷-4-醇(24.73%)。经HPLC指纹图谱分析, 北极蒿与其他三种植物主要成分相似, 但北极蒿的化学成分集中且含量高。青蒿、北极蒿、艾叶、茵陈中绿原酸含量分别是0.065%, 0.617%, 0.178%, 0.192%, 北极蒿中绿原酸含量是其它三种植物的六倍之多, 提示有较高研究价值。

关键词: 蒿属植物, 蒿属植物, 蒿属植物, 北极蒿, 北极蒿, 北极蒿, 青蒿, 青蒿, 青蒿, 艾叶, 艾叶, 艾叶, 茵陈, 茵陈, 茵陈

Abstract:

Aim To compare the chemical constituents of Artemisia borealis with three other Artemisia plants which are generally used in traditional Chinese medicine. Method The chemical components of essential oil from the leaves of A. borealis were analyzed by GC- MS and the chemical components of water extracts of the four plants were compared by HPLC fingerprint method. Conclusion From the essential oil of A. borealis, 52 peaks were separate, 48 of them were identified by GC-MS analysis, indicative that aromadendrane-4-ol is the highest constituent, which made up 24.73% of the total essential oil. In addition the chief constituents of the leaves of A.borealis are similar to the three other plants but its pattern of HPLC fingerprint is different. The content of chlorogenic acid in aerial part of A. annus and A. scapillaries, leaves of A. borealis and A. argyi are 0.065, 0.192, 0.617and 0.178 % respectively.

Key words: Artemisia, Artemisia, A. borealis, A. borealis, A. annua, A. annua, A. argyi, A. argyi, A. capillaries, A. capillaries

中图分类号:

Supporting: ^*Corresponding author. Tel.: 86-24-25857591

田芳, 刘丽, 窦德强^*, 康廷国, Smith David. 北极蒿与中药常用蒿属植物的化学成分比较[J]. .

Fang Tian, Li Liu, De-Qiang Dou^*, Ting-Guo Kang, Smith David. Chemical comparison of Artemisia borealis and three Chinese Artemisia plants[J]. .

[1]	应茵, 孙云峰, 李宏春, 羊波, 王晖, 吴青梅, 黄萍. 艾叶油对肺动脉高压大鼠的干预研究[J]. 中国药学(英文版), 2018, 27(3): 183-192.
[2]	代华灵, 高伟祺, 张国顺, 王锐利, 张淑秋. 青蒿素脂质纳米粒的制备及药动学评价[J]. 中国药学(英文版), 2017, 26(3): 180-186.
[3]	王舒, 姜勇, 曾克武, 崔景荣, 屠鹏飞^*. 艾叶中抗神经炎症的成分研究[J]. , 2013, 22(4): 377-380.
[4]	张晓云, 刘建平^*, 乔华, 黄奎源, 史彦斌, 宋淑梅, 倪京满. 2-羟丙基-β-环糊精(HP-β-CD)对双氢青蒿素水溶液的稳定性和溶解性的影响[J]. , 2009, 18(2): 170-176.
[5]	李莉欣, 苏艳芳, 刘晓峰, 果德安^*. 大黄毛状根对青蒿素的生物转化研究[J]. , 2002, 11(4): 122-124.
[6]	叶祖光, Carolyn Doak, Knox Van Dyke . 青蒿素对体外培养人恶性疟原虫不同生长期的选择性作用[J]. , 1993, 2(1): 64-68.