唐古特大黄化学成分研究

唐古特大黄化学成分研究

金伟, 格日立, 黄志勤, 魏全嘉, 包天佑, 屠鹏飞^*

1.北京大学医学部药学院, 北京 100083;
2.青海大学医学院, 青海西宁 810001;
3.赣南医学院, 江西赣州 341000

收稿日期:2006-06-15 修回日期:2006-11-10 出版日期:2006-12-15 发布日期:2006-12-15
通讯作者: 屠鹏飞*

Chemical Constituents of Rheum tanguticum Maxim.ex Balf.

JIN Wei, GE Ri-li, HUANG Zhi-qin, WEI Quan-jia, BAO Tian-you, TU Peng-fei^*

1. School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100083, China;
2. Qinghai University Medical College, Xining 810001, China;
3. Gannan Medical College, Ganzhou 341000, China

Received:2006-06-15 Revised:2006-11-10 Online:2006-12-15 Published:2006-12-15
Contact: TU Peng-fei*

摘要/Abstract

摘要： 目的研究唐古特大黄的化学成分。方法采用多种色谱技术进行分离纯化, 应用质谱、核磁等技术确定化合物的结构。结果从唐古特大黄的根和根茎中分离得到β-谷甾醇、大黄酚、芦荟大黄素、大黄素甲醚、大黄酸、大黄素等20个化合物。结论 4'-羟基苯基-2-丁酮(9)、4'-羟基苯基-2-丁酮-4'-O-β-D-(2''-O-桂皮酰基-6''-O-没食子酰基)-葡萄糖苷(12)和4'-羟基苯基-2-丁酮-4'-O-β-D-(2''-O-没食子酰基-6''-O-(4'''-羟基)-桂皮酰基)-葡萄糖苷(13)为首次从该种植物中分离得到。

关键词: 唐古特大黄, 唐古特大黄, 唐古特大黄, 4'-羟基苯基-2-丁酮, 4'-羟基苯基-2-丁酮, 4'-羟基苯基-2-丁酮, 4'-羟基苯基-2-丁酮-4'-O-β-D-2''-O-桂皮酰基-6''-O-没食子酰基-葡萄糖苷, 4'-羟基苯基-2-丁酮-4'-O-β-D-2''-O-桂皮酰基-6''-O-没食子酰基-葡萄糖苷, 4'-羟基苯基-2-丁酮-4'-O-β-D-2''-O-桂皮酰基-6''-O-没食子酰基-葡萄糖苷, 4'-羟基苯, 4'-羟基苯, 4'-羟基苯

Abstract:

Aim To study the chemical constituents of the root and rhizome of Rheum tanguticum Maxim. ex Balf. Methods Chemical constituents were isolated and purified by many chromatographic methods, and their structures were elucidated by MS, NMR, and others. Results Twenty compounds were isolated and their structures were identified as β-sitosterol, chrysophanol, aloe-emodin, physcion, rhein, emodin, etc. Conclusion Among these compounds, 4-(4'-hydroxyphenyl)-2-butanone, 4-(4'-hydroxyphenyl)-2-butanone-4'-O-β-D-(2''-O-cinnamoyl-6''-O-galloyl)-glucopyranoside and 4-(4'-hydroxyphenyl)-2-butanone-4'-O-β-D-(2''-O-galloyl-6''-O-p-coumaroyl)-glucopyranoside were isolated from the root and rhizome of Rheum tanguticum for the first time.

Key words: Rheum tanguticum Maxim ex Balf., Rheum tanguticum Maxim ex Balf., 4-(4'-hydroxyphenyl)-2-butanone, 4-(4'-hydroxyphenyl)-2-butanone, 4-(4'-hydroxyphenyl)-2-butanone-4'-O-β-D-(2''-O-cinnamoyl-6''-O-galloyl)-glucopyranoside, 4-(4'-hydroxyphenyl)-2-butanone-4'-O-β-D-(2''-O-cinnamoyl-6''-O-galloyl)-glucopyranoside, 4-(4'-hydroxyphenyl)-2-butanone-4'-O-β-D-(2''-O-galloyl-6''-O-p-coumaroyl)-glucopyranoside., 4-(4'-hydroxyphenyl)-2-butanone-4'-O-β-D-(2''-O-galloyl-6''-O-p-coumaroyl)-glucopyranoside.

中图分类号:

Supporting: Foundation item: Natural Research Foundation of Qinghai Province (No. 20042N2103202)
^*Corresponding author. Tel./fax: 86-10-82802750

金伟, 格日立, 黄志勤, 魏全嘉, 包天佑, 屠鹏飞^*. 唐古特大黄化学成分研究[J]. .

JIN Wei, GE Ri-li, HUANG Zhi-qin, WEI Quan-jia, BAO Tian-you, TU Peng-fei^*. Chemical Constituents of Rheum tanguticum Maxim.ex Balf.[J]. .

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