蛇床子素凝胶药物经皮吸收的体外研究

蛇床子素凝胶药物经皮吸收的体外研究

苑振亭, 丁平田^*, 吕波, 陈大为

1.沈阳药科大学药学院, 辽宁沈阳 110016;
2.解放军丹东230医院药剂科, 辽宁丹东 118000;
3.鞍山汤岗子医院药剂科, 辽宁鞍山 114000

收稿日期:2004-04-12 修回日期:2004-08-10 出版日期:2004-09-15 发布日期:2004-09-15
通讯作者: 丁平田*

In Vitro Skin Permeation of Osthol from Hydro-Alcoholic Gel Formulations

YUAN Zhen-ting, DING Ping-tian^*, Lu Bo, CHEN Da-wei

1.Shenyang Pharmaceutical University, Shenyang 110016, China;
2.Dandong 230 Military Hospital, Dandong 118000, China;
3.Anshan Tanggangzi Hospital, Anshan 114000, China

Received:2004-04-12 Revised:2004-08-10 Online:2004-09-15 Published:2004-09-15
Contact: DING Ping-tian*

摘要/Abstract

摘要： 目的体外测定含有渗透促进剂的蛇床子素凝胶经人体皮肤的吸收. 方法以离体人皮肤为渗透模型,应用Franz扩散池进行实验. 样品以高效液相法测定蛇床子素的含量. 结果与对照组相比,渗透促进剂Azone、薄荷醇、土荆芥油可以使得蛇床子素的稳态流量分别提高3.12、2.00、1.25倍. 结论三种渗透促进剂的作用机理为破坏了皮肤角质层的屏障作用, 降低了药物的扩散阻力, 因而提高了蛇床子素的扩散系数.

关键词: 蛇床子素, 蛇床子素, 蛇床子素, 经皮吸收, 经皮吸收, 经皮吸收, 凝胶, 凝胶, 凝胶, 渗透促进剂, 渗透促进剂, 渗透促进剂

Abstract: Aim To evaluate the in vitro percutaneous absorption behavior of osthol from a series of hydro-alcoholic gel formulations containing three penetration enhancers through excised human skin (stratum cormeum and epidermis,SCE). Methods Excised human skin was mounted in Franz-type diffusion cells. The samples withdrawn from the receptor cell were analyzed for osthol content by high-performance liquid chromatography (HPLC). Results The enhancers azone, menthol and chenopodium increased the osthol percutaneous steady-state fluxes 3.12, 2.00 and 1.25 times those of the enhancer-free formulations (controls), separately. Conclusions The main enhancement mechanism of the skin penetration enhancers azone, menthol and chenopodium is to destroy the barrier function of stratum corneum, reducing the resistance of drug transport through the skin and increasing the diffusion coefficients of osthol.

Key words: osthol, osthol, percutaneous absorption, percutaneous absorption, gel, gel, penetration enhancers, penetration enhancers

中图分类号:

R943.43

R944.15

Supporting: ^*Corresponding author. Tel.: 86-24-23843711-3661

苑振亭, 丁平田^*, 吕波, 陈大为. 蛇床子素凝胶药物经皮吸收的体外研究[J]. .

YUAN Zhen-ting, DING Ping-tian^*, Lu Bo, CHEN Da-wei. In Vitro Skin Permeation of Osthol from Hydro-Alcoholic Gel Formulations[J]. .

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