醉鱼草中的环烯醚萜苷

醉鱼草中的环烯醚萜苷

陆江海, 蒲小平, 涂光忠, 赵玉英^*

1.北京大学药学院, 北京 100083;
2.北京微量化学研究所, 北京 100091

收稿日期:2004-03-11 修回日期:2004-08-10 出版日期:2004-09-15 发布日期:2004-09-15
通讯作者: 赵玉英*

Iridoid Glycosides from Buddleja lindeyana

LU Jiang-hai, PU Xiao-ping, TU Guang-zhong, ZHAO Yu-ying^*

1.School of Pharmaceutical Sciences, Peking University,Beijing 100083, China;
2.Beijng Institute of Microchemistry, Beijing 100091, China

Received:2004-03-11 Revised:2004-08-10 Online:2004-09-15 Published:2004-09-15
Contact: ZHAO Yu-ying*

摘要/Abstract

摘要： 目的研究醉鱼草(Buddleja lindeyana)的活性成分. 方法应用多种色谱技术分离纯化, 用IR, MS和NMR等谱学方法解析化合物结构. 结果与结论 从醉鱼草(Buddleja lindeyana)的全草分离到5个化合物, 其中三个为环烯醚萜苷. 它们的结构为: 6-氧-阿魏酰筋骨草苷(1), 赤式-6-氧-4'-(3-甲氧基-4-羟基苯丙三醇-8")-阿魏酰筋骨草苷(2), 苏式-6-氧-4'-(3-甲氧基-4-羟基苯丙三醇-8'')-阿魏酰筋骨草苷(3), 二十四烷酸-α-单甘油脂(4), 半乳糖醇(5). 上述成分均为首次从醉鱼草中得到.且化合物1, 2和3对神经细胞有保护作用.

关键词: 醉鱼草, 醉鱼草, 醉鱼草, 环烯醚萜苷, 环烯醚萜苷, 环烯醚萜苷, 6-氧-阿魏酰筋骨草苷, 6-氧-阿魏酰筋骨草苷, 6-氧-阿魏酰筋骨草苷

Abstract: Aim To study the chemical constituents of Buddleja lindeyana. Methods The constituents were separated and purified by different methods of chromatography, and their structures were elucidated by IR, MS and NMR. Results Three iridoid glycosides and two other compounds were isolated from Buddleja lindeyana. Their structures were elucidated to be 6-O-feruloylajugol (1), erythro-6-oxo-4'-(3-methoxyl-4-hydroxyphenylglycol-8'')-feruloylaj-ugol (2), threo-6-oxo-4'-(3-methoxyl-4-hydroxyphenylglycol-8'')-feruloylajugol (3), tetra-cosanoic acid 2,3-dihydroxypropyl ester (4), and galactitol (5). Conclusion All the compounds have been isolated from this plant for the first time. Compounds 1, 2 and 3 have protective effect agains MPP⁺-induced apoptosis.

Key words: iridoid glycoside, iridoid glycoside, Buddleja lindeyana, Buddleja lindeyana, 6-O-feruloylajugol, 6-O-feruloylajugol

中图分类号:

R284.1

R284.2

R285.5

Supporting: Foundation item: National Natural Science Foundation of China (20172004).
^*Corresponding author. Tel.: 86-10-82801592; fax: 86-10-82801592

陆江海, 蒲小平, 涂光忠, 赵玉英^*. 醉鱼草中的环烯醚萜苷[J]. .

LU Jiang-hai, PU Xiao-ping, TU Guang-zhong, ZHAO Yu-ying^*. Iridoid Glycosides from Buddleja lindeyana[J]. .

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