苯丙素苷及其类似物的合成研究

苯丙素苷及其类似物的合成研究

李树春, 周静, 李中军^*

1.北京大学药学院化学生物学系, 北京 100083;
2.石河子大学药学院, 新疆石河子市 832002

收稿日期:2003-10-15 修回日期:2004-02-10 出版日期:2004-03-15 发布日期:2004-03-15
通讯作者: 李中军*

Synthesis of Phenylpropanoid Glycoside Analogs

LI Shu-chun, ZHOU Jing, LI Zhong-jun^*

1. Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China;
2. School of Pharmaceutical Sciences, Shihezi University, Shihezi Xinjiang 832002, China

Received:2003-10-15 Revised:2004-02-10 Online:2004-03-15 Published:2004-03-15
Contact: LI Zhong-jun*

摘要/Abstract

摘要： 利用葡萄糖6位羟基活性较高的特性, 2-(取代)苯乙基-β-D-吡喃葡萄糖苷在低温条件下直接与(取代)肉桂酰氯反应, 区域选择性地生成6位酰化的葡萄糖苷, 利用此方法很方便的得到了13个苯丙素苷类似物, 利用¹H NMR 和¹³C NMR方法确证了他们的结构.

关键词: 药物化学, 药物化学, 区域选择性酰化, 区域选择性酰化, 苯丙素苷, 苯丙素苷, 葡萄糖苷类似物, 葡萄糖苷类似物, 化学合成, 化学合成

Abstract: The regioselective acylation of unprotected phenylethyl glucoside with cinnamoyl chloride leads to 6-OH cinnamoylated glucoside.In this manner, thirteen phenylpropanoid glycoside analogs were designed and prepared.Their structure was confirmed by ¹H NMR and ¹³C NMR spectra.

Key words: medicinal chemistry, medicinal chemistry, regioselective acylation, regioselective acylation, phenylpropanoid glycoside, phenylpropanoid glycoside, glycoside analogs, glycoside analogs, chemical synthesis, chemical synthesis

中图分类号:

R916.4

R917.02

Supporting: Foundation item: National Natural Science Foundation of China (30070887).
^*Corresponding author. Tel.: 010-82801504; fax: 010-62367134

李树春, 周静, 李中军^*. 苯丙素苷及其类似物的合成研究[J]. .

LI Shu-chun, ZHOU Jing, LI Zhong-jun^*. Synthesis of Phenylpropanoid Glycoside Analogs[J]. .

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