蘡薁中分离的多酚化合物

蘡薁中分离的多酚化合物

窦德强^*, 任杰, Maggie Cooper, 何曜华, 裴玉萍, Yoshiaki Takaya, Masatake Niwa, 陈英杰, 姚新生, 周仁平

1.沈阳药科大学天然药化教研室;
2.日本Meijo大学药学院;
3.美国Rutgers大学化学生物系

收稿日期:2002-12-29 修回日期:2003-05-10 出版日期:2003-06-15 发布日期:2003-06-15
通讯作者: 窦德强*

Polyphenols from Vitis thunbergii Sieb. et Zucc.

DOU De-qiang^*, REN Jie, Maggie Cooper , HE Yue-hua, PEI Yu-ping, Yoshiaki Takaya, Masatake Niwa, CHEN Ying-jie, YAO Xin-sheng, ZHOU Ren-ping

1.Department of Natural Products Chemistry, Shenyang Pharmaceutical University,Shenyang 110016,China;
2.Faculty of Pharmacy, Meijo University, Japan;
3.Department of Chemical Biology, Rutgers University, USA

Received:2002-12-29 Revised:2003-05-10 Online:2003-06-15 Published:2003-06-15
Contact: DOU De-qiang*

摘要/Abstract

摘要： 目的分离鉴定蘡薁地上部分的化学成分。方法通过硅胶柱色谱,SephadexLH-20及制备HPLC方法分离, 对其进行理化常数和光谱分析确定结构。结果自蘡薁地上部分分离得到11个多酚化合物,均属首次分离。结论化合物1为新化合物, 经鉴定其结构为3,5-二甲氧基-4-羟基苯丙醇-9-氧-β-D-吡喃葡萄糖苷。

关键词: 蘡薁, 苯丙醇葡萄糖苷, 多酚

Abstract: Aim Isolation and structural elucidation of the constituents from the aerial part of Vitis thunbergii. Methods To isolate chemical constituents, column chromatography and HPLC were used. Physico-chemical characterization and spectroscopic analysis were employed for structural identification. Results Eleven polyphenols were isolated and identified. Conclusion Compound 1 is a new compound and its structure was characterized to be 3,5-dimethoxyl-4-hydroxyl-phenyl-propanol-9-O-β-D-glycopyranoside.

Key words: Vitis thunbergii, Vitis thunbergii, phenylpropanol glycoside, phenylpropanol glycoside, polyphenol, polyphenol

中图分类号:

R284.2

Supporting: ^*Corresponding author. Tel.: 024-23882129

窦德强^*, 任杰, Maggie Cooper, 何曜华, 裴玉萍, Yoshiaki Takaya, Masatake Niwa, 陈英杰, 姚新生, 周仁平. 蘡薁中分离的多酚化合物[J]. .

DOU De-qiang^*, REN Jie, Maggie Cooper , HE Yue-hua, PEI Yu-ping, Yoshiaki Takaya, Masatake Niwa, CHEN Ying-jie, YAO Xin-sheng, ZHOU Ren-ping. Polyphenols from Vitis thunbergii Sieb. et Zucc.[J]. .

[1]	乔自鹏, 王奇志, 刘建福, 王明元. 胜红蓟内生真菌乙酸乙酯提取物的抗氧化及抑菌活性研究[J]. 中国药学(英文版), 2021, 30(5): 421-433.
[2]	陈楠, 梁晓霞. 紫花玉簪内生真菌分离鉴定及其抗氧化活性研究[J]. 中国药学(英文版), 2018, 27(10): 711-718.
[3]	费文波, 梁晓霞, 何敏. 利用HPLC测定诃子的两种传统藏药炮制品中多酚类成分含量的变化[J]. 中国药学(英文版), 2016, 25(2): 150-153.
[4]	王艳丽, 黄伟, 陈帅, 陈石泉, 王世范^*. 天然多酚衍生物的合成、结构和酪氨酸酶抑制作用[J]. , 2011, 20(3): 235-244.
[5]	韩梅^*, 李金凤, 谭祺, 孙媛媛, 王永炎. MTT方法在药物筛选研究中的应用限制[J]. , 2010, 19(3): 195-200.
[6]	赵月斌, 施喆, 叶丽华, 刘会雪^, 杨晓达^, 王夔. 槲皮素和茶多酚抑制VO(acac)₂导致的线粒体损伤和细胞毒性 [J]. , 2009, 18(3): 225-231.
[7]	何冰, 陈小夏, 陈一岳. 茶多酚对脑缺血再灌注损伤的保护作用及在体外抗脂质过氧化和清除自由基作用[J]. , 2002, 11(4): 157-161.