氯化乙烯镁制备的改进及其应用

氯化乙烯镁制备的改进及其应用

李安良

北京大学药学院, 北京, 100083

收稿日期:2002-04-21 修回日期:2002-07-03 出版日期:2002-09-15 发布日期:2002-09-15

Improvement on Preparation of Vinylmagnesium Chloride and Its Application

Li Anliang

School of Pharmaceutical Sciences, Peking University, Beijing 100083

Received:2002-04-21 Revised:2002-07-03 Online:2002-09-15 Published:2002-09-15

摘要/Abstract

摘要： 本文是氯化乙烯镁制备的改进.新方法可防止氯乙烯的逃逸,简化操作.其重要进步是革除-45°C的深度冷冻. 将该格氏试剂用于合成乙烯基-β-紫罗兰醇和6-甲氧基-1-乙烯基-萘满醇, 证实它的用途. 它们分别是异维甲酸及米非司酮的中间体.

关键词: 氯化乙烯镁, 深度冷冻, 异维甲酸, 米非司酮

Abstract: An improvement on the preparation of vinylmagnesium chloride is described. The new approach prevents vinyl chloride from escaping and simplifies the operation. The important advantage is that it would get rid of -45°C deep cooling. The Grignard reagent was used to test its application and qualification for the synthesis of vimyl-β-ionol or 6-methoxy-1-vinyl-1-tetralol. The former is an intermediate of isotretinoin and the latter is an intermediate of mifepristone norgestrel or norgetriene.

Key words: Vinylmagnesium chloride, Vinylmagnesium chloride, Deep cooling, Deep cooling, Isotretinoin, Isotretinoin, Mifepristone, Mifepristone

Supporting:

李安良. 氯化乙烯镁制备的改进及其应用[J]. .

Li Anliang. Improvement on Preparation of Vinylmagnesium Chloride and Its Application[J]. .

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