苦山柰的二萜化学成分

苦山柰的二萜化学成分

余竞光, 余冬蕾, 孙兰, 章菽, 郑才成, 陈毓亨

1.中国医学科学院中国协和医科大学药用植物研究所, 北京 100094;
2.中国医学科学院中国协和医科大学药物研究所, 北京 100050

收稿日期:2001-02-02 修回日期:2001-05-07 出版日期:2001-06-15 发布日期:2001-06-15

The Chemical Constituents of Diterpenoids from Kaempferia marginata Carey

Yu Jingguang, Yu Donglei, Sun Lan, Zhang Shu, Zheng Caicheng, Chen Yuheng

1. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094;
2. Institute of Meteria Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050

Received:2001-02-02 Revised:2001-05-07 Online:2001-06-15 Published:2001-06-15

摘要/Abstract

摘要： 从中药山柰的混杂品种苦山柰根茎分得一个新二萜苦山柰萜醇(marginatol 1) 和5个已知化合物:8(14),15-sanderacopimaradiene-1α,9α-diol(2), 8(14), 15-sanderacopimaradiene-1α,6β,9α-triol(3) 以及吉马酮(4), 对-甲氧基-肉桂酸乙酯(5) 和正-十五烷(6)。根据光谱数据(IR, MS, ¹H-¹H, ¹³C-¹H NMR, NOESY 和HMBC) 分析,确定苦山柰萜醇(1)的化学结构为8(14),15-isopimaradiene-6β-ol。化合物2,3 和4是首次从该植物分得。

关键词: 苦山柰, 姜科, 二萜醇, 苦山柰萜醇

Abstract: Marginatol (1), a new isopimarene diterpenoid, and five known compounds 8(14),15-sanderacopimaradiene-1α,9α-diol (2), 8(14),15-sanderacopimaradene-1α,6β,9α-triol (3), germacrone (4), trans-ethyl p-methoxycinnamate (5) and n-pentadecane (6) were isolated from the hexane extract of Kaempferia marginata Carey. The structure of marginatol (1) was established as 8(14),15-isopimaradiene-6β-ol on the basis of spectral data (IR, MS, ¹H-¹H, ¹³C-¹H NMR, NOESY and HMBC). Compounds 2, 3 and 4 were isolated for the first time from this plant.

Key words: Kaempferia marginata Carey, Zingiberaceae, Diterpenoids, Marginatol

Supporting: ^*First published in Chinese in Acta Pharmaceutica Sinica, 2000, 35(10): 761.

余竞光, 余冬蕾, 孙兰, 章菽, 郑才成, 陈毓亨. 苦山柰的二萜化学成分[J]. .

Yu Jingguang, Yu Donglei, Sun Lan, Zhang Shu, Zheng Caicheng, Chen Yuheng . The Chemical Constituents of Diterpenoids from Kaempferia marginata Carey[J]. .