肝动脉栓塞用莪术油明胶微球的体外释放的研究

肝动脉栓塞用莪术油明胶微球的体外释放的研究

邓嵘, 陈济民, 高声传

1. 沈阳药科大学药剂教研室, 沈阳 110015;
2. 沈阳军区总医院药剂科, 沈阳 110015

收稿日期:1999-10-29 修回日期:2000-03-07 出版日期:2000-09-15 发布日期:2000-09-15

In Vitro Drug Release Characteristics of Gelatin Microspheres Containing Zedoary Turmeric Oil for Hepatical Arterial Embolization

Deng Rong , Chen Jimin, Gao Shengchuan

1. Department of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110015;
2. Department of Pharmacy, General Hospital of Shenyang Command of PLA, Shenyang, 110015

Received:1999-10-29 Revised:2000-03-07 Online:2000-09-15 Published:2000-09-15

摘要/Abstract

摘要： 采用连续流动系法对肝动脉栓塞用莪术油明胶微球的体外释放特性进行了研究,结果表明不同的流速、介质、交联剂用量及交联时间和微球的粒径均对体外释放有影响,但灭菌对微球的体外释放无影响。12 小时后,释放80%的药物。药物从微球中的释放符合一级动力学模型,释放机制为溶蚀加扩散。

关键词: 莪术油, 莪术醇, 明胶微球, 体外释放

Abstract: The properties of gelatin microspheres Zedoary turmeric oil (GMS-ZT) in vitro release were studied by the continuous flow system (CFS), which could simulate the actual state in vivo. The effects of sterilization, different flow rates, release medium, the amount of formaldehyde, the duration of cross-linking and the size of microspheres on the drug release were investigated. The results showed that these factors except the sterilization had influences on drug release and the drug release from the microspheres was slow. Eighty percent of the drug released after 12 h, and the release profiles in vitro could be described by the first-order dynamic model, and drug release was controlled by the matrix erosion and diffusion.

Key words: Zedoary turmeric oil, Zedoary turmeric oil, Curcumol, Curcumol, Gelatin microspheres, Gelatin microspheres, Drug release in vitro, Drug release in vitro

Supporting:

邓嵘, 陈济民, 高声传. 肝动脉栓塞用莪术油明胶微球的体外释放的研究[J]. .

Deng Rong , Chen Jimin, Gao Shengchuan . In Vitro Drug Release Characteristics of Gelatin Microspheres Containing Zedoary Turmeric Oil for Hepatical Arterial Embolization[J]. .

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