利用中效原理对化疗联合用药的效应分析

利用中效原理对化疗联合用药的效应分析

陆洪娣, 汤为学, 周剑芳

重庆医科大学数理教研室, 重庆 400016

收稿日期:1998-07-07 修回日期:1999-06-15 出版日期:1999-12-15 发布日期:1999-12-15

Analysis of the Combination Chemotherapy Effect In Vitro Utilizing the Median-effect Principle

Lu Hongdi, Tang Weixue, Zhou Jianfang

Department of Maths and Physics. Chongqing University of medical Sciences, Chongqing 400016;

Received:1998-07-07 Revised:1999-06-15 Online:1999-12-15 Published:1999-12-15

摘要/Abstract

摘要： 介绍利用中效原理设计电脑程序分析化疗联合用药体外药敏实验的效应。本程序所需要的试验次数较少, 不但能确定两种药物是否协同, 而且能分析药物剂量变化时联合效应的变化情况。可为癌症化疗个体化治疗方案的制定提供参考。

关键词: 联合化疗, 药敏试验, 中效原理

Abstract: In this paper, the median-effect principle was used to design a computer programto evaluate the combination chemotherapy effect in vitro. This program requires fewer tests and cannot only determine whether the interaction of two drugs is synergic, but also analyse the synergicefficiency with changing dosages. It can be used as a reference for the design of combination chemotherapy in clinical practice.

Key words: Combination chemotherapy, Drug sensitivity test, Median-effect principle

Supporting:

陆洪娣, 汤为学, 周剑芳. 利用中效原理对化疗联合用药的效应分析[J]. .

Lu Hongdi, Tang Weixue, Zhou Jianfang. Analysis of the Combination Chemotherapy Effect In Vitro Utilizing the Median-effect Principle[J]. .