蔓生百部新生物碱的化学研究

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蔓生百部新生物碱的化学研究

邹长英, 付宏征, 雷海民, 李军, 林文翰^*

北京医科大学天然药物及仿生药物国家重点实验室, 北京 100083

收稿日期:1999-05-20 修回日期:1999-09-28 出版日期:1999-12-15 发布日期:1999-12-15
通讯作者: 林文翰*

New Alkaloids from the Roots of Stemona japonica Miq.

Zou Changying, Fu Hongzheng, Lei Haimin, Li Jun, Lin Wenhan^*

National Research Laboratories of Natural and Biomimetic Drugs, Beijing Medical University Beijing 100083

Received:1999-05-20 Revised:1999-09-28 Online:1999-12-15 Published:1999-12-15
Contact: Lin Wenhan*

摘要/Abstract

摘要： 从国产蔓生百部根部, 分得五种新的生物碱, 分别是对叶百部碱B(1)、对叶百部碱C(2)、脱氢对叶百部碱B(3)、脱氢对叶百部碱C(4)和异丽江百部碱(5)。它们的结构经IR、MS和各种2DNMR技术, 结合同类物的波谱对照得以阐明, 其中1为对叶百部碱的C-15差向异构体, 2为1的C-9差向异构体, 3和4分别为1和2的perhydroazaazulene环脱氢产物, 5为丽江百部碱不饱和内酯的螺环异构体。

关键词: 蔓生百部, 对叶百部碱B, 对叶百部碱C, 脱氢对叶百部碱B, 脱氢对叶百部碱C, 异丽江百部碱

Abstract:

From the roots of Stemona japonica(Miq), five new alkaloids, namely tuberostemonine B(1), tuberostemonine C(2), bisdehydrotuberostemonine B(3), bisdehydrotuberostemonine C(4) and isomaistemonine(5) have been isolated. Their structures were elucidated by 2D NMR, IR andMS, in comparison with the spectral data of their analogues. Compound 1 was a C-10 isomer oftuberostemonine and compound 2 was a C-9 isomer of 1. Compounds 3 and 4 were identified as thedidehydrogenated products of tuberostemonine B and tuberostemonine C respectively due to theoxidation transformation. Compound 5 was the unsaturated lactone spiral isomer of maistemonine.

Key words: Stemona japonica Miq, Stemona japonica Miq, Tuberostemonine B, Tuberostemonine B, Tuberostemonine C, Tuberostemonine C, Bisdehydrotuberostemonine B, Bisdehydrotuberostemonine B, Bisdehydrotuberostemonine C, Isomaistemonine, Bisdehydrotuberostemonine C, Isomaistemonine

Supporting:

邹长英, 付宏征, 雷海民, 李军, 林文翰^*. 蔓生百部新生物碱的化学研究[J]. .

Zou Changying, Fu Hongzheng, Lei Haimin, Li Jun, Lin Wenhan^*. New Alkaloids from the Roots of Stemona japonica Miq.[J]. .