低分子量肝素的抗过敏作用

低分子量肝素的抗过敏作用

王庆利, 尚雪原, 张世玲

山东医科大学药学院药理学教研室, 济南 250012

收稿日期:1998-09-22 修回日期:1999-01-27 出版日期:1999-09-15 发布日期:1999-09-15

Anti-allergic Effects of Low Molecular Weight Heparin

Wang Qingli, Shang Xueyuan, Zhang Shiling

Department of Pharmacology, College of Parmacy, Shandong Medical University, Jinan 250012

Received:1998-09-22 Revised:1999-01-27 Online:1999-09-15 Published:1999-09-15

摘要/Abstract

摘要： 低分子量肝素是新发展起来的一种生化药物, 具有多种非抗凝活性。研究结果显示, LMWH 16000 u·L^-1(P<0.01)和8000 u·L^-1(P<0.05)均能显著降低OA所致的致敏豚鼠离体回肠平滑肌收缩高度; LMWH 200u·kg^-1, 50 u·kg^-1和12.5 u·kg^-1(P<0.01)均能明显抑制颅骨骨膜肥大细胞脱颗粒; LMWH 60 u·kg^-1 (P<0.01)和30 u·kg^-1 (P<0.05)均能显著减少个氨基吡啶诱发的小鼠舔体反应次数,并能抑制冰乙酸所致的小鼠毛细血管通透性增加。结果表明LMWH对多种动物模型具有抗过敏的作用, 这种作用可能与其抑制肥大细胞脱颗粒和抗炎作用有关。

关键词: 低分子量肝素, 抗过敏作用, 肥大细胞

Abstract: Low molecular weight heparin(LMWH), a newly developed biodrug, possesses multiple non-anticoagulant activities. Our results showed that LMWH at the concentrations of 16000and 8000 u·L^-1 could significantly (P<0.01, P<0.05 vs vehicle) inhibit constriction of isolated ileum smooth muscle of ovalbumin (OA)-sensitized guinea pigs induced by OA in vitro, LMWH 200, 50and 12.5 u·kg^-1 ip could markedly (P<0.01 vs vehicle) inhibit degranulation of pericranium MC in rats, LMWH 60 and 30 u·kg^-1 ip could significantly (P<0.01, P<0.05 vs vehicle) depress the licking response induced by 4-aminopridine and the increasing of capillary permeability induced by aceticacid in mice. These results indicated that LMWH in the dosages used in the present study possessed anti-allergic activity in several animal models, and the activity was related to its inhibitory effects on the degranulation of MC and to its anti-inflammatory effect.

Key words: Low molecular weight heparin, Anti-allergic effect, Mast cell

Supporting:

王庆利, 尚雪原, 张世玲. 低分子量肝素的抗过敏作用[J]. .

Wang Qingli, Shang Xueyuan, Zhang Shiling. Anti-allergic Effects of Low Molecular Weight Heparin[J]. .

[1]	彭华, 马金魁, 程洁, 黄成志, 张宏斌. Lipocalin噬菌体文库的构建及与FcεRI-α受体结合分子的初步筛选[J]. 中国药学(英文版), 2019, 28(11): 770-777.
[2]	马俊江, 斯拉甫, 林志彬. N-(3',4',5'-三甲氧基肉桂酰)邻氨基苯甲酸对抗原诱发的离体豚鼠回肠收缩、大鼠肥大细胞脱颗粒及组胺释放的影响 [J]. , 1992, 1(1): 41-45.