用带有弯曲进样管的程序升温汽化进样器进样CGC法测定注射液中丙二醇含量

用带有弯曲进样管的程序升温汽化进样器进样CGC法测定注射液中丙二醇含量

凌笑梅, 徐秉玖

北京医科大学药学院, 北京 100083

收稿日期:1998-03-28 修回日期:1998-12-10 出版日期:1999-06-15 发布日期:1999-06-15

CGC Measurement of Propylene Glycol Content with Bentport Programmed Temperature Vaporizing (PTV) Injector

Ling Xiaomei, Xu Bingjiu

School of Pharmaceutical Sciences, Beijing Medical University Beijing 100083

Received:1998-03-28 Revised:1998-12-10 Online:1999-06-15 Published:1999-06-15

摘要/Abstract

摘要： 本文采用带有弯曲进样管程序升温汽化进样器进样, 毛细管气相色谱(CGC)法测定注射液中丙二醇含量, 实验结果表明: 这种方法不仅比常规CGC中采用的分流方法能得到更为准确和精密的结果(回收率约99%, RSD<2%), 分析周期短(<7分钟), 测定时不需预处理直接进稀释样即可, 不存在损伤毛细柱的可能; 而且比迄今发表的程序升温汽化进样(PTV)方法也有优越之处。

关键词: CGC, 注射液中丙二醇, 带有弯曲进样管程序升温技术

Abstract: This paper describes a CGC method to measure propylene glycol content in injection of 8-chloro-adenosine by injecting into a new PTV injector with bent-port vaporizing tube. This new method has the following advantages over split injection: it results in higher accuracy and precision (RSD ca. 2%, recovery ca. 99%), its analytical Period is short (<7 min), pretreatment of the sample is not necessary, and capillary column is not damaged after hundreds of samples injected. In comparison with PTV techniques published so far, this novel injector is superior in several respects.

Key words: CGC, Propylene glycol in injection, PTV with bent open injector tube

Supporting:

凌笑梅, 徐秉玖. 用带有弯曲进样管的程序升温汽化进样器进样CGC法测定注射液中丙二醇含量[J]. .

Ling Xiaomei, Xu Bingjiu. CGC Measurement of Propylene Glycol Content with Bentport Programmed Temperature Vaporizing (PTV) Injector[J]. .