鱼油(EPA和DHA)对麻醉大鼠左室功能的影响

鱼油(EPA和DHA)对麻醉大鼠左室功能的影响

张芳, 周建政^*, 吴葆杰, 张岫美

山东医科大学基础部药理学教研室, 济南 250012;
现通讯地址：北京市军事医学科学院毒物药物研究所 100850

收稿日期:1994-11-17 修回日期:1996-06-29 出版日期:1996-12-15 发布日期:1996-12-15
通讯作者: 周建政*

Effect of Fish Oil on Left Ventricular Function in Anes-thetized Rats

Fang Zhang, Jian-Zheng Zhou^*, Bao-Jie Wu, Xiu-Mei Zhang

Department of Pharmacology, Shandong Medical University, Jinan 250012

Received:1994-11-17 Revised:1996-06-29 Online:1996-12-15 Published:1996-12-15
Contact: Jian-Zheng Zhou*

摘要/Abstract

摘要： 本文观察了鱼油对麻醉大鼠基础左室功能和异丙肾上腺素(ISO) 诱导的左室功能改变的影响。实验结果表明, 鱼油 (EPA和DHA, 70%, 1.4 ml/kg) 摄入两周对大鼠基础心功能无显著影响, 但可显著地抑制ISO (0.4 μg/kg, 4.0 μg/kg, 40 μg/kg) 诱导的正性肌力和正性频率作用, 对ISO诱导的心室前负荷的改变却大显著影响, 结果提示鱼油的摄入可能影响大鼠心肌细胞膜上β-受体的功能。

关键词: 鱼油, EPA和DHA, 左室功能, 异丙肾上腺素, β-受体

Abstract: The effect of fish oil on the basal left ventricular function and changes of left ventricular function induced by isoproterenol (ISO) were demonstrated in our study. The detennina-tion of cardiac perfonnance in vivo showed that supplementation with fish oil (EPA and DHA, 70%, 1.4 ml/kg) had no significant effect on basal cardiac perfonnance, while it could significantly inhibit changes of +dp/dtmax, Vpm and HR induced by ISO (0.4 μg/ kg, 4.0 μg/ kg, 40 μg/ kg) intrave-nously.The results suggested that supplementation with fish oil perhaps affected the function of β-adrenoceptors on rat myocardial membrane.

Key words: Fish oil, EPA and DHA, Left ventricular function, β-adrenoceptor

Supporting: Present address: Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850.

张芳, 周建政^*, 吴葆杰, 张岫美. 鱼油(EPA和DHA)对麻醉大鼠左室功能的影响[J]. .

Fang Zhang, Jian-Zheng Zhou^*, Bao-Jie Wu, Xiu-Mei Zhang. Effect of Fish Oil on Left Ventricular Function in Anes-thetized Rats[J]. .