关键词: 阿魏硝胺, 尼可地尔, 离体工作心脏, 血管舒张

Abstract: The cardiac and vascular effect of ethanolamine nitrate ester ferulate (ENF) wasinvestigated on isolated working guinea pig heart (IWH) and rat aortic ring. The coronary blood flowwas remarkably increased while the cardiac functions of IWH were not significantly altered by ENFranging from 10-8 to 10^-4 mol/L. The percentages of vasorelaxation of ENF (10 μmol/L) and nicoran-dil (NIC, 10 μmol/L) on K⁺ (80 mmol/L)-induced contraction in aortic rings were 72±8% and17±8%, respectively. The relaxation effects of ENF and NIC on phenylephrine (PE, 5 μmol/L) in-duced contraction were in a dose-dependent manner. When vessel segments were exposed to PE withmethylene blue (MB, 10 μmol/L) or with glibenclamide (GLI, 10 μmol/L), the percentages of relaxa-tion of ENF (10 μmol/L) and NIC ( 10 μmol/L) were 41±11% and 49±7% or 76±14% and the 33±9%, respectively. The results suggested that ENF improved coronary circulation and the vasodilation of ENF was mediated bv nitrate-like action.

Key words: Ethanolamine nitrate ester ferulate. Nicorandil. Cardiac function, Vasodilation, lsolated working heart