海人草酸损伤大鼠苍白球后脑内单胺递质水平的变化

海人草酸损伤大鼠苍白球后脑内单胺递质水平的变化

周建政, 董华进, 肖文彬

北京军事医学科学院毒物药物研究所, 北京 100850

收稿日期:1994-09-05 修回日期:1995-09-18 出版日期:1995-12-15 发布日期:1995-12-15

Changes of Monoanine Levelsin Different Brain Regionsof Rat with Ventral Giobus Pailidus Injuredby Kainic Acid Injection

Jian-Zheng Zhou, Hua-Jin Dong, Wen Xiao

Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850

Received:1994-09-05 Revised:1995-09-18 Online:1995-12-15 Published:1995-12-15

摘要/Abstract

摘要：

用海人草酸毁损大鼠苍白球造成老年性痴呆模型并在海马, 额皮层。纹状体及延髓脑桥部四个不同胞区测定了单胺递质水平的变化。在此模型中, 大鼠海马和额皮层的去甲肾上腺素(NE)水平显著低于正常对照, 说明在以上脑区去甲肾上腺素能神经已遭损伤。多巴胺(DA)水平在四个脑区均有所降低, 其中在额皮层和纹状体降低显著, 同时在大脑额皮层, 纹状体和延髓脑桥部, DA转化率均显著降低。结果提示, 在此模型中, DA代谢可能出现紊乱。5羟色胺水平和多巴胺-β-羟化酶(DBH)活性(用NE/DA的比率表示)同正常对照相比无显著性差异。结果显示此模型基本上反映了老年性痴呆病人脑中单胺递质水平的变化, 可以作为老年性痴呆模型用于基础医学与治疗研究。

关键词: 老年性痴呆, 苍白球, 海人草酸, 单胺递质

Abstract: Ventral globus pallidus-injured rats by kainic acid(10 mg) were used to derter-mine the monoamine levels in four different brain regions.In this model, a great decrease of NE con-centration was observed in both hippocampus and frontal cortex compared with nonnal contro. This result hints that a damage of noradrenergic neurons in this model has occurred. DA concentrations in the four brain zones after kainic acid injection were all reduced, but only in the frontal cortex and striatum the pronounced reductions were discovered while DA turnover rates in frontal cortex, stria-tum and meddullapons were significantly reduced. These results revealed a DA metabolic disorder occurring in these regions.However, 5-HT concentrations as well as DBH activity, expressed by ratio of NE/DA, showed no marked difference in this model. In our study it is found that the changes of monoamine levels in this model basically reflect those discovered in AD patients.

Key words: Alzheimer disease (AD), Monoamine, Kainic acid, Ventral globus pallidus

Supporting:

周建政, 董华进, 肖文彬. 海人草酸损伤大鼠苍白球后脑内单胺递质水平的变化[J]. .

Jian-Zheng Zhou, Hua-Jin Dong, Wen Xiao. Changes of Monoanine Levelsin Different Brain Regionsof Rat with Ventral Giobus Pailidus Injuredby Kainic Acid Injection[J]. .